GO Annotations Graph

• Symbol: Chrna4
• Name: cholinergic receptor, nicotinic, alpha polypeptide 4
• ID: MGI:87888

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042166	acetylcholine binding	ISO	J:155856
Molecular Function	GO:0015464	acetylcholine receptor activity	ISO	J:164563
Molecular Function	GO:0015464	acetylcholine receptor activity	IDA	J:179572
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	ISO	J:164563
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	ISO	J:155856
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	IBA	J:265628
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	IMP	J:78831
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	IMP	J:93873
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	IGI	J:94804
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	TAS	J:64208
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	IMP	J:109365
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	IMP	J:109365
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	IGI	J:99085
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	IMP	J:93873
Molecular Function	GO:0005230	extracellular ligand-gated monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:155856
Molecular Function	GO:0005216	monoatomic ion channel activity	IDA	J:75439
Molecular Function	GO:0005515	protein binding	IPI	J:225865
Molecular Function	GO:0005515	protein binding	IPI	J:85306
Molecular Function	GO:0005515	protein binding	IPI	J:85306
Molecular Function	GO:0005515	protein binding	IPI	J:75439
Molecular Function	GO:0005515	protein binding	IPI	J:146775
Molecular Function	GO:0005515	protein binding	IPI	J:149519
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0050997	quaternary ammonium group binding	ISO	J:155856
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Molecular Function	GO:1904315	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO	J:155856
Cellular Component	GO:0005892	acetylcholine-gated channel complex	ISO	J:164563
Cellular Component	GO:0005892	acetylcholine-gated channel complex	ISO	J:155856
Cellular Component	GO:0005892	acetylcholine-gated channel complex	ISO	J:164563
Cellular Component	GO:0005892	acetylcholine-gated channel complex	IDA	J:225865
Cellular Component	GO:0005892	acetylcholine-gated channel complex	IPI	J:122030
Cellular Component	GO:0005892	acetylcholine-gated channel complex	IDA	J:179572
Cellular Component	GO:0005892	acetylcholine-gated channel complex	IDA	J:85306
Cellular Component	GO:0098981	cholinergic synapse	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0098691	dopaminergic synapse	IMP	J:263384
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:263384
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:85306
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:85306
Cellular Component	GO:0098691	dopaminergic synapse	IMP	J:85306
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:103908
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:146775
Cellular Component	GO:0016020	membrane	IDA	J:75439
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:99085
Cellular Component	GO:0005886	plasma membrane	IDA	J:225865
Cellular Component	GO:0045211	postsynaptic membrane	IEA	J:60000
Cellular Component	GO:0045211	postsynaptic membrane	IEA	J:72247
Cellular Component	GO:0099634	postsynaptic specialization membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:212011
Cellular Component	GO:0042734	presynaptic membrane	IEP	J:212011
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:212011
Cellular Component	GO:0042734	presynaptic membrane	IMP	J:263384
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:263384
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0045202	synapse	IBA	J:265628
Biological Process	GO:0095500	acetylcholine receptor signaling pathway	IDA	J:225865
Biological Process	GO:0042113	B cell activation	IMP	J:103908
Biological Process	GO:0035095	behavioral response to nicotine	ISO	J:164563
Biological Process	GO:0035095	behavioral response to nicotine	IMP	J:93873
Biological Process	GO:0006816	calcium ion transport	IGI	J:94804
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0050890	cognition	ISO	J:164563
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0035640	exploration behavior	IMP	J:64208
Biological Process	GO:0060080	inhibitory postsynaptic potential	IMP	J:118273
Biological Process	GO:0060080	inhibitory postsynaptic potential	IMP	J:118273
Biological Process	GO:0060080	inhibitory postsynaptic potential	IMP	J:118273
Biological Process	GO:0060080	inhibitory postsynaptic potential	IMP	J:118273
Biological Process	GO:0007626	locomotory behavior	IMP	J:67863
Biological Process	GO:0051899	membrane depolarization	ISO	J:164563
Biological Process	GO:0051899	membrane depolarization	IDA	J:314381
Biological Process	GO:0051899	membrane depolarization	IGI	J:99085
Biological Process	GO:0051899	membrane depolarization	IMP	J:109365
Biological Process	GO:0051899	membrane depolarization	IMP	J:67863
Biological Process	GO:0051899	membrane depolarization	IMP	J:85306
Biological Process	GO:0051899	membrane depolarization	IMP	J:109365
Biological Process	GO:0034220	monoatomic ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0050877	nervous system process	ISO	J:164563
Biological Process	GO:0050877	nervous system process	IBA	J:265628
Biological Process	GO:0050877	nervous system process	IMP	J:118273
Biological Process	GO:0050877	nervous system process	IMP	J:118273
Biological Process	GO:0019228	neuronal action potential	IMP	J:54505
Biological Process	GO:0019228	neuronal action potential	IMP	J:54505
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IMP	J:85306
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:85306
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:85306
Biological Process	GO:1903048	regulation of acetylcholine-gated cation channel activity	ISO	J:155856
Biological Process	GO:0014059	regulation of dopamine secretion	IMP	J:85306
Biological Process	GO:0042391	regulation of membrane potential	IBA	J:265628
Biological Process	GO:0042391	regulation of membrane potential	IGI	J:94804
Biological Process	GO:0007585	respiratory gaseous exchange by respiratory system	IMP	J:173338
Biological Process	GO:1905144	response to acetylcholine	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0035094	response to nicotine	ISO	J:164563
Biological Process	GO:0035094	response to nicotine	IGI	J:99085
Biological Process	GO:0035094	response to nicotine	IMP	J:54505
Biological Process	GO:0035094	response to nicotine	IDA	J:179572
Biological Process	GO:0006979	response to oxidative stress	ISO	J:164563
Biological Process	GO:0019233	sensory perception of pain	IMP	J:54505
Biological Process	GO:0019233	sensory perception of pain	TAS	J:64208
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0007271	synaptic transmission, cholinergic	ISO	J:155856
Biological Process	GO:0007271	synaptic transmission, cholinergic	IDA	J:75439
Biological Process	GO:0007271	synaptic transmission, cholinergic	IMP	J:67863