GO Annotations Graph

• Symbol: Acta2
• Name: actin alpha 2, smooth muscle, aorta
• ID: MGI:87909

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0019901	protein kinase binding	IPI	J:169453
Cellular Component	GO:0015629	actin cytoskeleton	IDA	J:126330
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:33779
Cellular Component	GO:0005604	basement membrane	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:79955
Cellular Component	GO:0005737	cytoplasm	IDA	J:125521
Cellular Component	GO:0005737	cytoplasm	IDA	J:268890
Cellular Component	GO:0005737	cytoplasm	IDA	J:319546
Cellular Component	GO:0005737	cytoplasm	IDA	J:174203
Cellular Component	GO:0005856	cytoskeleton	IDA	J:114396
Cellular Component	GO:0031514	motile cilium	IDA	J:319546
Cellular Component	GO:0030485	smooth muscle contractile fiber	IDA	J:136004
Cellular Component	GO:0030485	smooth muscle contractile fiber	IDA	J:136004
Cellular Component	GO:0001725	stress fiber	ISO	J:155856
Biological Process	GO:0006936	muscle contraction	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:2000491	positive regulation of hepatic stellate cell activation	ISO	J:155856
Biological Process	GO:0061874	positive regulation of hepatic stellate cell contraction	ISO	J:155856
Biological Process	GO:0061870	positive regulation of hepatic stellate cell migration	ISO	J:155856
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:113261
Biological Process	GO:0061041	regulation of wound healing	ISO	J:155856
Biological Process	GO:0014829	vascular associated smooth muscle contraction	IMP	J:113261