Acvr1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Acvr1
activin A receptor, type 1
MGI:87911

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048185	activin binding	ISO	J:164563
Molecular Function	GO:0048185	activin binding	IPI	J:11226
Molecular Function	GO:0048185	activin binding	IPI	J:27756
Molecular Function	GO:0016361	activin receptor activity, type I	ISO	J:164563
Molecular Function	GO:0016361	activin receptor activity, type I	ISO	J:155856
Molecular Function	GO:0016361	activin receptor activity, type I	IDA	J:69633
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0045296	cadherin binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	IDA	J:25557
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:93750
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	IDA	J:77383
Molecular Function	GO:0005025	transforming growth factor beta receptor activity, type I	IBA	J:265628
Molecular Function	GO:0005025	transforming growth factor beta receptor activity, type I	IDA	J:25557
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72247
Cellular Component	GO:0048179	activin receptor complex	ISO	J:155856
Cellular Component	GO:0048179	activin receptor complex	ISO	J:164563
Cellular Component	GO:0045177	apical part of cell	IDA	J:61348
Cellular Component	GO:0045177	apical part of cell	IDA	J:68348
Cellular Component	GO:0070724	BMP receptor complex	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:69633
Biological Process	GO:0032924	activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002526	acute inflammatory response	IEP	J:116258
Biological Process	GO:0003289	atrial septum primum morphogenesis	ISO	J:164563
Biological Process	GO:0003289	atrial septum primum morphogenesis	IMP	J:103532
Biological Process	GO:0003181	atrioventricular valve morphogenesis	IMP	J:103532
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IBA	J:265628
Biological Process	GO:0061312	BMP signaling pathway involved in heart development	IMP	J:103532
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:119667
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:119667
Biological Process	GO:0060923	cardiac muscle cell fate commitment	ISO	J:164563
Biological Process	GO:0071773	cellular response to BMP stimulus	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	IBA	J:265628
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:95020
Biological Process	GO:0009953	dorsal/ventral pattern formation	IBA	J:265628
Biological Process	GO:0009790	embryo development	IMP	J:87407
Biological Process	GO:0009790	embryo development	IMP	J:90453
Biological Process	GO:0009790	embryo development	IMP	J:90453
Biological Process	GO:0009790	embryo development	IMP	J:90453
Biological Process	GO:0009790	embryo development	IMP	J:90453
Biological Process	GO:0003143	embryonic heart tube morphogenesis	ISO	J:164563
Biological Process	GO:0061445	endocardial cushion cell fate commitment	ISO	J:164563
Biological Process	GO:0003274	endocardial cushion fusion	IMP	J:103532
Biological Process	GO:0003203	endocardial cushion morphogenesis	IMP	J:103532
Biological Process	GO:0007369	gastrulation	IMP	J:54394
Biological Process	GO:0001702	gastrulation with mouth forming second	IMP	J:117234
Biological Process	GO:0001702	gastrulation with mouth forming second	IMP	J:117234
Biological Process	GO:0007281	germ cell development	IMP	J:91660
Biological Process	GO:0007507	heart development	IBA	J:265628
Biological Process	GO:0007507	heart development	IMP	J:119667
Biological Process	GO:0007507	heart development	IMP	J:90988
Biological Process	GO:0007507	heart development	IMP	J:103532
Biological Process	GO:0001701	in utero embryonic development	IMP	J:90453
Biological Process	GO:0001701	in utero embryonic development	IMP	J:87407
Biological Process	GO:0001701	in utero embryonic development	IMP	J:117234
Biological Process	GO:0001701	in utero embryonic development	IMP	J:90453
Biological Process	GO:0001701	in utero embryonic development	IMP	J:117234
Biological Process	GO:0007498	mesoderm development	IMP	J:117234
Biological Process	GO:0007498	mesoderm development	IMP	J:117234
Biological Process	GO:0001707	mesoderm formation	IMP	J:117234
Biological Process	GO:0001707	mesoderm formation	IMP	J:57670
Biological Process	GO:0001707	mesoderm formation	IMP	J:117234
Biological Process	GO:0003183	mitral valve morphogenesis	ISO	J:164563
Biological Process	GO:0032926	negative regulation of activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0009968	negative regulation of signal transduction	ISO	J:164563
Biological Process	GO:0001755	neural crest cell migration	IMP	J:90988
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0060037	pharyngeal system development	IMP	J:119667
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0030501	positive regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:2000017	positive regulation of determination of dorsal identity	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP	J:103532
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IMP	J:103532
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:103532
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0030278	regulation of ossification	ISO	J:164563
Biological Process	GO:0051145	smooth muscle cell differentiation	IMP	J:119667
Biological Process	GO:0051145	smooth muscle cell differentiation	IMP	J:119667
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	TAS	J:77383
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:69633
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IEA	J:72247
Biological Process	GO:0001655	urogenital system development	ISO	J:73065
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:103532

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24