GO Annotations Graph

• Symbol: Adra2a
• Name: adrenergic receptor, alpha 2a
• ID: MGI:87934

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004935	adrenergic receptor activity	IMP	J:105642
Molecular Function	GO:0031696	alpha-2C adrenergic receptor binding	ISO	J:164563
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	ISO	J:164563
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	ISO	J:155856
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	IBA	J:265628
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	IMP	J:130781
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	TAS	J:77486
Molecular Function	GO:0051379	epinephrine binding	ISO	J:164563
Molecular Function	GO:0051379	epinephrine binding	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0032795	heterotrimeric G-protein binding	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	IMP	J:130781
Molecular Function	GO:0051380	norepinephrine binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:41995
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0031996	thioesterase binding	ISO	J:164563
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0098691	dopaminergic synapse	EXP	J:126644
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:126644
Cellular Component	GO:0098691	dopaminergic synapse	IMP	J:126644
Cellular Component	GO:0098691	dopaminergic synapse	IMP	J:126644
Cellular Component	GO:0098691	dopaminergic synapse	EXP	J:126644
Cellular Component	GO:0098691	dopaminergic synapse	IDA	J:126644
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0048787	presynaptic active zone membrane	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0032147	activation of protein kinase activity	ISO	J:164563
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:164563
Biological Process	GO:0002526	acute inflammatory response	ISO	J:155856
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	J:265628
Biological Process	GO:0071881	adenylate cyclase-inhibiting adrenergic receptor signaling pathway	ISO	J:164563
Biological Process	GO:0071875	adrenergic receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032870	cellular response to hormone stimulus	ISO	J:164563
Biological Process	GO:0006260	DNA replication	ISO	J:155856
Biological Process	GO:0042596	fear response	IMP	J:89367
Biological Process	GO:0007565	female pregnancy	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IDA	J:105642
Biological Process	GO:0042593	glucose homeostasis	ISO	J:155856
Biological Process	GO:0042593	glucose homeostasis	ISO	J:164563
Biological Process	GO:0045955	negative regulation of calcium ion-dependent exocytosis	ISO	J:155856
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0046676	negative regulation of insulin secretion	IMP	J:329318
Biological Process	GO:0046676	negative regulation of insulin secretion	IDA	J:329318
Biological Process	GO:0046676	negative regulation of insulin secretion	IMP	J:130781
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:164563
Biological Process	GO:0050995	negative regulation of lipid catabolic process	ISO	J:164563
Biological Process	GO:0070473	negative regulation of uterine smooth muscle contraction	ISO	J:155856
Biological Process	GO:0071882	phospholipase C-activating adrenergic receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030168	platelet activation	IEA	J:72247
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:164563
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0090303	positive regulation of wound healing	ISO	J:164563
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	EXP	J:126644
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:126644
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IMP	J:126644
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	EXP	J:126644
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:126644
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IMP	J:126644
Biological Process	GO:0035624	receptor transactivation	ISO	J:164563
Biological Process	GO:0006940	regulation of smooth muscle contraction	IEA	J:72247
Biological Process	GO:0019229	regulation of vasoconstriction	IEA	J:72247
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0050955	thermoception	ISO	J:155856
Biological Process	GO:0042311	vasodilation	ISO	J:155856