GO Annotations Graph

• Symbol: Adra2b
• Name: adrenergic receptor, alpha 2b
• ID: MGI:87935

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004935	adrenergic receptor activity	IMP	J:105642
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	ISO	J:155856
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	ISO	J:164563
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	IBA	J:265628
Molecular Function	GO:0004938	alpha2-adrenergic receptor activity	IDA	J:77486
Molecular Function	GO:0051379	epinephrine binding	ISO	J:164563
Molecular Function	GO:0051379	epinephrine binding	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:41995
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:164563
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	J:265628
Biological Process	GO:0071875	adrenergic receptor signaling pathway	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IMP	J:77486
Biological Process	GO:0007565	female pregnancy	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IDA	J:105642
Biological Process	GO:0000165	MAPK cascade	IMP	J:77486
Biological Process	GO:0030168	platelet activation	IEA	J:72247
Biological Process	GO:0045777	positive regulation of blood pressure	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:164563
Biological Process	GO:0070474	positive regulation of uterine smooth muscle contraction	ISO	J:155856
Biological Process	GO:0035624	receptor transactivation	ISO	J:164563
Biological Process	GO:0006940	regulation of smooth muscle contraction	IEA	J:72247
Biological Process	GO:0003056	regulation of vascular associated smooth muscle contraction	ISO	J:155856
Biological Process	GO:0019229	regulation of vasoconstriction	IEA	J:72247
Biological Process	GO:0007165	signal transduction	IEA	J:60000