GO Annotations Graph

• Symbol: Adrb1
• Name: adrenergic receptor, beta 1
• ID: MGI:87937

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004935	adrenergic receptor activity	IEA	J:72247
Molecular Function	GO:0031694	alpha-2A adrenergic receptor binding	ISO	J:164563
Molecular Function	GO:0043176	amine binding	ISO	J:155856
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	ISO	J:155856
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	IBA	J:265628
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	IDA	J:25102
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	IMP	J:34659
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	IMP	J:34659
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	IDA	J:43208
Molecular Function	GO:0099579	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IDA	J:263472
Molecular Function	GO:0099579	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IMP	J:263472
Molecular Function	GO:0099579	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	EXP	J:263472
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:131299
Molecular Function	GO:0005515	protein binding	IPI	J:172115
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IMP	J:34659
Cellular Component	GO:0016020	membrane	IMP	J:34659
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	EXP	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:263472
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:263472
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	EXP	J:263472
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	ISO	J:164563
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:34659
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0050873	brown fat cell differentiation	IGI	J:79769
Biological Process	GO:0050873	brown fat cell differentiation	IGI	J:79769
Biological Process	GO:0002024	diet induced thermogenesis	IGI	J:79309
Biological Process	GO:0002024	diet induced thermogenesis	IGI	J:79309
Biological Process	GO:0042596	fear response	IMP	J:89376
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0005980	glycogen catabolic process	ISO	J:155856
Biological Process	GO:0031649	heat generation	IGI	J:79309
Biological Process	GO:0031649	heat generation	IGI	J:79309
Biological Process	GO:0060080	inhibitory postsynaptic potential	ISO	J:155856
Biological Process	GO:0055088	lipid homeostasis	ISO	J:155856
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IGI	J:79769
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IGI	J:79769
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0035811	negative regulation of urine volume	ISO	J:155856
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA	J:265628
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IGI	J:102882
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP	J:55553
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP	J:102882
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IGI	J:55553
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	ISO	J:155856
Biological Process	GO:0106071	positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1905665	positive regulation of calcium ion import across plasma membrane	ISO	J:155856
Biological Process	GO:2001259	positive regulation of cation channel activity	ISO	J:155856
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IGI	J:79769
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:249901
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0045823	positive regulation of heart contraction	IEA	J:72247
Biological Process	GO:0010460	positive regulation of heart rate	ISO	J:155856
Biological Process	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	IBA	J:265628
Biological Process	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	IMP	J:55553
Biological Process	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	IMP	J:34659
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:1900135	positive regulation of renin secretion into blood stream	ISO	J:155856
Biological Process	GO:0046878	positive regulation of saliva secretion	ISO	J:155856
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	ISO	J:155856
Biological Process	GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	IDA	J:37034
Biological Process	GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	IMP	J:34659
Biological Process	GO:0003061	positive regulation of the force of heart contraction by norepinephrine	ISO	J:155856
Biological Process	GO:0033365	protein localization to organelle	ISO	J:155856
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	ISO	J:155856
Biological Process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	ISO	J:164563
Biological Process	GO:0045187	regulation of circadian sleep/wake cycle, sleep	IMP	J:279954
Biological Process	GO:0009409	response to cold	IGI	J:79769
Biological Process	GO:0009409	response to cold	IGI	J:79309
Biological Process	GO:0009409	response to cold	IGI	J:79309
Biological Process	GO:0009409	response to cold	IGI	J:79769
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:155856
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0042060	wound healing	ISO	J:155856