GO Annotations Graph

• Symbol: Adrb2
• Name: adrenergic receptor, beta 2
• ID: MGI:87938

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008179	adenylate cyclase binding	IDA	J:140381
Molecular Function	GO:0004935	adrenergic receptor activity	IEA	J:72247
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0031713	B2 bradykinin receptor binding	ISO	J:155856
Molecular Function	GO:0004941	beta2-adrenergic receptor activity	ISO	J:164563
Molecular Function	GO:0004941	beta2-adrenergic receptor activity	ISO	J:155856
Molecular Function	GO:0004941	beta2-adrenergic receptor activity	IBA	J:265628
Molecular Function	GO:0004941	beta2-adrenergic receptor activity	IDA	J:34659
Molecular Function	GO:0004941	beta2-adrenergic receptor activity	IDA	J:7332
Molecular Function	GO:0004941	beta2-adrenergic receptor activity	IDA	J:30115
Molecular Function	GO:0004941	beta2-adrenergic receptor activity	IDA	J:43208
Molecular Function	GO:0004941	beta2-adrenergic receptor activity	IDA	J:34659
Molecular Function	GO:0004941	beta2-adrenergic receptor activity	IDA	J:72097
Molecular Function	GO:0004941	beta2-adrenergic receptor activity	IDA	J:25102
Molecular Function	GO:0019899	enzyme binding	IPI	J:198908
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0001965	G-protein alpha-subunit binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	ISO	J:155856
Molecular Function	GO:0051380	norepinephrine binding	ISO	J:164563
Molecular Function	GO:0051380	norepinephrine binding	IBA	J:265628
Molecular Function	GO:0015459	potassium channel regulator activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:116074
Molecular Function	GO:0005515	protein binding	IPI	J:172115
Molecular Function	GO:0005515	protein binding	IPI	J:109447
Molecular Function	GO:0005515	protein binding	IPI	J:41995
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0051721	protein phosphatase 2A binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0090722	receptor-receptor interaction	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:87186
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:30115
Cellular Component	GO:0016020	membrane	IDA	J:7332
Cellular Component	GO:0032809	neuronal cell body membrane	ISO	J:155856
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	EXP	J:326640
Cellular Component	GO:0098992	neuronal dense core vesicle	IDA	J:326640
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:98241
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-421961
Cellular Component	GO:0005886	plasma membrane	ISO	J:41995
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Biological Process	GO:0007190	activation of adenylate cyclase activity	ISO	J:164563
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:97566
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:30115
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:72097
Biological Process	GO:0071875	adrenergic receptor signaling pathway	ISO	J:164563
Biological Process	GO:0008306	associative learning	ISO	J:155856
Biological Process	GO:0097746	blood vessel diameter maintenance	IEA	J:72247
Biological Process	GO:0045453	bone resorption	IMP	J:97566
Biological Process	GO:0050873	brown fat cell differentiation	IGI	J:79769
Biological Process	GO:0050873	brown fat cell differentiation	IGI	J:79769
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:164563
Biological Process	GO:1904646	cellular response to amyloid-beta	IGI	J:241478
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:155856
Biological Process	GO:0002032	desensitization of G protein-coupled receptor signaling pathway by arrestin	ISO	J:164563
Biological Process	GO:0002086	diaphragm contraction	ISO	J:155856
Biological Process	GO:0002024	diet induced thermogenesis	IGI	J:79309
Biological Process	GO:0002024	diet induced thermogenesis	IGI	J:79309
Biological Process	GO:0060079	excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0031649	heat generation	IGI	J:79309
Biological Process	GO:0031649	heat generation	IGI	J:79309
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IGI	J:79769
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IGI	J:79769
Biological Process	GO:0030279	negative regulation of ossification	ISO	J:155856
Biological Process	GO:0090331	negative regulation of platelet aggregation	ISO	J:155856
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	IBA	J:265628
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	IGI	J:85126
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	IGI	J:85126
Biological Process	GO:0035811	negative regulation of urine volume	ISO	J:155856
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA	J:265628
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP	J:55553
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IGI	J:102882
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IGI	J:55553
Biological Process	GO:2000969	positive regulation of AMPA receptor activity	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0032781	positive regulation of ATP-dependent activity	ISO	J:155856
Biological Process	GO:1901098	positive regulation of autophagosome maturation	ISO	J:164563
Biological Process	GO:0030501	positive regulation of bone mineralization	IMP	J:97566
Biological Process	GO:1905665	positive regulation of calcium ion import across plasma membrane	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IGI	J:79769
Biological Process	GO:0045823	positive regulation of heart contraction	ISO	J:155856
Biological Process	GO:1904504	positive regulation of lipophagy	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0061885	positive regulation of mini excitatory postsynaptic potential	IGI	J:241478
Biological Process	GO:0043268	positive regulation of potassium ion transport	ISO	J:155856
Biological Process	GO:0010739	positive regulation of protein kinase A signaling	ISO	J:164563
Biological Process	GO:0010739	positive regulation of protein kinase A signaling	IGI	J:241478
Biological Process	GO:0071902	positive regulation of protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0048633	positive regulation of skeletal muscle tissue growth	ISO	J:155856
Biological Process	GO:0010765	positive regulation of sodium ion transport	ISO	J:155856
Biological Process	GO:0003059	positive regulation of the force of heart contraction by epinephrine	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:97566
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0006940	regulation of smooth muscle contraction	IEA	J:72247
Biological Process	GO:0002028	regulation of sodium ion transport	IMP	J:98914
Biological Process	GO:0001993	regulation of systemic arterial blood pressure by norepinephrine-epinephrine	IMP	J:55552
Biological Process	GO:0071869	response to catecholamine	ISO	J:155856
Biological Process	GO:0009409	response to cold	IGI	J:79309
Biological Process	GO:0009409	response to cold	IGI	J:79309
Biological Process	GO:0009409	response to cold	IGI	J:79769
Biological Process	GO:0009409	response to cold	IGI	J:79769
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0006939	smooth muscle contraction	IGI	J:85126
Biological Process	GO:0006939	smooth muscle contraction	IGI	J:85126
Biological Process	GO:0035249	synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:97566
Biological Process	GO:0042311	vasodilation	ISO	J:155856
Biological Process	GO:0042060	wound healing	ISO	J:155856