GO Annotations Graph

• Symbol: Adrb3
• Name: adrenergic receptor, beta 3
• ID: MGI:87939

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004935	adrenergic receptor activity	IEA	J:72247
Molecular Function	GO:0031699	beta-3 adrenergic receptor binding	IDA	J:43208
Molecular Function	GO:0031699	beta-3 adrenergic receptor binding	IDA	J:25102
Molecular Function	GO:0004939	beta-adrenergic receptor activity	ISO	J:164563
Molecular Function	GO:0015052	beta3-adrenergic receptor activity	ISO	J:164563
Molecular Function	GO:0015052	beta3-adrenergic receptor activity	IBA	J:265628
Molecular Function	GO:0051379	epinephrine binding	ISO	J:155856
Molecular Function	GO:0051379	epinephrine binding	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0051380	norepinephrine binding	ISO	J:164563
Molecular Function	GO:0051380	norepinephrine binding	ISO	J:155856
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:25102
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Biological Process	GO:0007190	activation of adenylate cyclase activity	ISO	J:164563
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:25102
Biological Process	GO:0050873	brown fat cell differentiation	IGI	J:79769
Biological Process	GO:0050873	brown fat cell differentiation	IGI	J:79769
Biological Process	GO:0002024	diet induced thermogenesis	IGI	J:79309
Biological Process	GO:0002024	diet induced thermogenesis	IGI	J:79309
Biological Process	GO:0042755	eating behavior	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0031649	heat generation	IGI	J:79309
Biological Process	GO:0031649	heat generation	IGI	J:79309
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IGI	J:79769
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IGI	J:79769
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA	J:265628
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IDA	J:55553
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IGI	J:79769
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:30060
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0009409	response to cold	IGI	J:79309
Biological Process	GO:0009409	response to cold	IGI	J:79769
Biological Process	GO:0009409	response to cold	IGI	J:79309
Biological Process	GO:0009409	response to cold	IGI	J:79769
Biological Process	GO:0007165	signal transduction	IEA	J:60000