GO Annotations Graph

• Symbol: Grk2
• Name: G protein-coupled receptor kinase 2
• ID: MGI:87940

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0047696	beta-adrenergic receptor kinase activity	ISO	J:155856
Molecular Function	GO:0031850	delta-type opioid receptor binding	ISO	J:155856
Molecular Function	GO:0031755	Edg-2 lysophosphatidic acid receptor binding	ISO	J:164563
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:155856
Molecular Function	GO:0001664	G protein-coupled receptor binding	IBA	J:265628
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	ISO	J:164563
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	ISO	J:155856
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	IBA	J:265628
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	IMP	J:36567
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	IDA	J:11373
Molecular Function	GO:0004703	G protein-coupled receptor kinase activity	IDA	J:88364
Molecular Function	GO:0031851	kappa-type opioid receptor binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:105642
Molecular Function	GO:0005515	protein binding	IPI	J:122283
Molecular Function	GO:0005515	protein binding	IPI	J:105642
Molecular Function	GO:0005515	protein binding	IPI	J:122283
Molecular Function	GO:0004672	protein kinase activity	IDA	J:105642
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:122283
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005929	cilium	TAS	Reactome:R-MMU-5632663
Cellular Component	GO:0005929	cilium	TAS	Reactome:R-MMU-5632665
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:105642
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0060048	cardiac muscle contraction	ISO	J:164563
Biological Process	GO:1990869	cellular response to chemokine	ISO	J:155856
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	ISO	J:155856
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	IGI	J:37034
Biological Process	GO:0002029	desensitization of G protein-coupled receptor signaling pathway	IMP	J:55312
Biological Process	GO:0042699	follicle-stimulating hormone signaling pathway	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IDA	J:88364
Biological Process	GO:0007507	heart development	IMP	J:36567
Biological Process	GO:0007507	heart development	IMP	J:36567
Biological Process	GO:0007507	heart development	IMP	J:36567
Biological Process	GO:0007507	heart development	IMP	J:36567
Biological Process	GO:0051457	maintenance of protein location in nucleus	ISO	J:155856
Biological Process	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1900077	negative regulation of cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:2000117	negative regulation of cysteine-type endopeptidase activity	ISO	J:155856
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0046325	negative regulation of glucose import	ISO	J:155856
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	ISO	J:155856
Biological Process	GO:1901081	negative regulation of relaxation of smooth muscle	ISO	J:164563
Biological Process	GO:1901081	negative regulation of relaxation of smooth muscle	IMP	J:292433
Biological Process	GO:0045988	negative regulation of striated muscle contraction	ISO	J:164563
Biological Process	GO:0003108	negative regulation of the force of heart contraction by chemical signal	ISO	J:164563
Biological Process	GO:0048709	oligodendrocyte differentiation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:122283
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	IDA	J:122283
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0033605	positive regulation of catecholamine secretion	ISO	J:155856
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0010661	positive regulation of muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:1904058	positive regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:105642
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0002026	regulation of the force of heart contraction	IBA	J:265628
Biological Process	GO:0002026	regulation of the force of heart contraction	IGI	J:37034
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0007217	tachykinin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0042311	vasodilation	ISO	J:155856
Biological Process	GO:0046718	viral entry into host cell	ISO	J:164563
Biological Process	GO:0019079	viral genome replication	ISO	J:164563