GO Annotations Graph

• Symbol: Alpl
• Name: alkaline phosphatase, liver/bone/kidney
• ID: MGI:87983

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004035	alkaline phosphatase activity	ISO	J:155856
Molecular Function	GO:0004035	alkaline phosphatase activity	ISO	J:164563
Molecular Function	GO:0004035	alkaline phosphatase activity	IBA	J:265628
Molecular Function	GO:0004035	alkaline phosphatase activity	IDA	J:120537
Molecular Function	GO:0004035	alkaline phosphatase activity	IDA	J:21480
Molecular Function	GO:0004035	alkaline phosphatase activity	IDA	J:130731
Molecular Function	GO:0004035	alkaline phosphatase activity	ISO	J:11608
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016791	phosphatase activity	IEA	J:72247
Molecular Function	GO:0050187	phosphoamidase activity	IDA	J:306607
Molecular Function	GO:0052732	phosphoethanolamine phosphatase activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0033883	pyridoxal phosphatase activity	ISO	J:164563
Molecular Function	GO:0016462	pyrophosphatase activity	IDA	J:314086
Molecular Function	GO:0016462	pyrophosphatase activity	IMP	J:179862
Molecular Function	GO:0016462	pyrophosphatase activity	ISO	J:73065
Cellular Component	GO:0031012	extracellular matrix	IDA	J:179862
Cellular Component	GO:0065010	extracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0065010	extracellular membrane-bounded organelle	IDA	J:179862
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005758	mitochondrial intermembrane space	IDA	J:306607
Cellular Component	GO:0031966	mitochondrial membrane	IDA	J:306607
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:21480
Cellular Component	GO:0005886	plasma membrane	IDA	J:120537
Biological Process	GO:0031214	biomineral tissue development	IEA	J:60000
Biological Process	GO:0030282	bone mineralization	IMP	J:314754
Biological Process	GO:0030282	bone mineralization	IMP	J:78130
Biological Process	GO:0030282	bone mineralization	IMP	J:314565
Biological Process	GO:0030282	bone mineralization	IMP	J:39015
Biological Process	GO:0030282	bone mineralization	IMP	J:173678
Biological Process	GO:0030282	bone mineralization	IMP	J:88444
Biological Process	GO:0030282	bone mineralization	IMP	J:77731
Biological Process	GO:0030282	bone mineralization	IGI	J:77731
Biological Process	GO:0030282	bone mineralization	IGI	J:77731
Biological Process	GO:0030282	bone mineralization	IGI	J:98814
Biological Process	GO:0030282	bone mineralization	IMP	J:77731
Biological Process	GO:0030282	bone mineralization	IGI	J:98814
Biological Process	GO:0030282	bone mineralization	IMP	J:98814
Biological Process	GO:0030282	bone mineralization	IMP	J:77731
Biological Process	GO:0030282	bone mineralization	IMP	J:77731
Biological Process	GO:0030282	bone mineralization	IGI	J:77731
Biological Process	GO:0030282	bone mineralization	IMP	J:77731
Biological Process	GO:0030282	bone mineralization	IGI	J:77731
Biological Process	GO:0030282	bone mineralization	IGI	J:77731
Biological Process	GO:0030282	bone mineralization	IGI	J:77731
Biological Process	GO:0030282	bone mineralization	IMP	J:77731
Biological Process	GO:0030282	bone mineralization	IMP	J:98814
Biological Process	GO:0055074	calcium ion homeostasis	IDA	J:173773
Biological Process	GO:0055074	calcium ion homeostasis	ISO	J:252837
Biological Process	GO:0055074	calcium ion homeostasis	IMP	J:252837
Biological Process	GO:0019725	cellular homeostasis	IMP	J:77731
Biological Process	GO:0019725	cellular homeostasis	IGI	J:77731
Biological Process	GO:0019725	cellular homeostasis	IMP	J:77731
Biological Process	GO:0019725	cellular homeostasis	IGI	J:77731
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:97016
Biological Process	GO:0016311	dephosphorylation	IBA	J:265628
Biological Process	GO:0003006	developmental process involved in reproduction	IGI	J:122954
Biological Process	GO:0001958	endochondral ossification	IMP	J:173678
Biological Process	GO:0140651	futile creatine cycle	IDA	J:306607
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	IMP	J:173773
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	IMP	J:173773
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	IDA	J:173773
Biological Process	GO:0055062	phosphate ion homeostasis	IMP	J:77731
Biological Process	GO:0055062	phosphate ion homeostasis	IGI	J:77731
Biological Process	GO:0055062	phosphate ion homeostasis	IDA	J:173773
Biological Process	GO:0055062	phosphate ion homeostasis	IMP	J:173773
Biological Process	GO:0055062	phosphate ion homeostasis	IMP	J:77731
Biological Process	GO:0055062	phosphate ion homeostasis	IGI	J:77731
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IDA	J:306607
Biological Process	GO:0042822	pyridoxal phosphate metabolic process	IDA	J:28394
Biological Process	GO:0046677	response to antibiotic	IDA	J:11608
Biological Process	GO:0051384	response to glucocorticoid	ISO	J:155856
Biological Process	GO:1904383	response to sodium phosphate	IDA	J:201223
Biological Process	GO:1904383	response to sodium phosphate	IMP	J:77731
Biological Process	GO:1904383	response to sodium phosphate	IGI	J:77731
Biological Process	GO:0034516	response to vitamin B6	IMP	J:77731
Biological Process	GO:0034516	response to vitamin B6	IGI	J:77731