GO Annotations Graph

• Symbol: Alas2
• Name: aminolevulinic acid synthase 2, erythroid
• ID: MGI:87990

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	ISO	J:155856
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	IDA	J:322688
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	IDA	J:8626
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	IBA	J:265628
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	IMP	J:28141
Molecular Function	GO:0003870	5-aminolevulinate synthase activity	ISO	J:73065
Molecular Function	GO:0016746	acyltransferase activity	IEA	J:60000
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0120225	coenzyme A binding	ISO	J:155856
Molecular Function	GO:0030170	pyridoxal phosphate binding	IEA	J:72247
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005743	mitochondrial inner membrane	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	IEA	J:72247
Cellular Component	GO:0005739	mitochondrion	IDA	J:8626
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	ISO	J:73065
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0009058	biosynthetic process	IEA	J:72247
Biological Process	GO:0048821	erythrocyte development	IBA	J:265628
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:116367
Biological Process	GO:0006783	heme biosynthetic process	IMP	J:116367
Biological Process	GO:0006783	heme biosynthetic process	IBA	J:265628
Biological Process	GO:0042541	hemoglobin biosynthetic process	IMP	J:116367
Biological Process	GO:0042541	hemoglobin biosynthetic process	IBA	J:265628
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:58508
Biological Process	GO:0006778	porphyrin-containing compound metabolic process	IEA	J:72247
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0033014	tetrapyrrole biosynthetic process	IEA	J:72247