GO Annotations Graph

• Symbol: Alox5
• Name: arachidonate 5-lipoxygenase
• ID: MGI:87999

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	IMP	J:284993
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	ISO	J:164563
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	IDA	J:206711
Molecular Function	GO:0004051	arachidonate 5-lipoxygenase activity	IBA	J:265628
Molecular Function	GO:0051213	dioxygenase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005506	iron ion binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:142670
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:79448
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0005635	nuclear envelope	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	IBA	J:265628
Cellular Component	GO:0005641	nuclear envelope lumen	ISO	J:164563
Cellular Component	GO:0016363	nuclear matrix	ISO	J:164563
Cellular Component	GO:0031965	nuclear membrane	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:79448
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Biological Process	GO:0002526	acute inflammatory response	ISO	J:155856
Biological Process	GO:0036336	dendritic cell migration	IMP	J:122095
Biological Process	GO:0042593	glucose homeostasis	IMP	J:137920
Biological Process	GO:0006959	humoral immune response	IMP	J:168089
Biological Process	GO:0006954	inflammatory response	IMP	J:75371
Biological Process	GO:0002232	leukocyte chemotaxis involved in inflammatory response	ISO	J:164563
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	IMP	J:284986
Biological Process	GO:1901753	leukotriene A4 biosynthetic process	IMP	J:284993
Biological Process	GO:1901753	leukotriene A4 biosynthetic process	ISO	J:164563
Biological Process	GO:0019370	leukotriene biosynthetic process	IMP	J:68714
Biological Process	GO:0019370	leukotriene biosynthetic process	ISO	J:164563
Biological Process	GO:0019370	leukotriene biosynthetic process	IDA	J:142670
Biological Process	GO:0006691	leukotriene metabolic process	IMP	J:75371
Biological Process	GO:0002540	leukotriene production involved in inflammatory response	IMP	J:39229
Biological Process	GO:0043651	linoleic acid metabolic process	IBA	J:265628
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0034440	lipid oxidation	IBA	J:265628
Biological Process	GO:2001301	lipoxin biosynthetic process	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	IMP	J:171000
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	IMP	J:171000
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:1903573	negative regulation of response to endoplasmic reticulum stress	IMP	J:253033
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	IMP	J:171000
Biological Process	GO:0061044	negative regulation of vascular wound healing	IMP	J:208193
Biological Process	GO:0061045	negative regulation of wound healing	IMP	J:208193
Biological Process	GO:0061045	negative regulation of wound healing	IMP	J:284986
Biological Process	GO:0030501	positive regulation of bone mineralization	IMP	J:285027
Biological Process	GO:1904960	positive regulation of cytochrome-c oxidase activity	ISO	J:155856
Biological Process	GO:1904999	positive regulation of leukocyte adhesion to arterial endothelial cell	IMP	J:219262
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:1900407	regulation of cellular response to oxidative stress	IMP	J:253033
Biological Process	GO:1900015	regulation of cytokine production involved in inflammatory response	IMP	J:284986
Biological Process	GO:0045598	regulation of fat cell differentiation	IMP	J:285027
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:253033
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:21372
Biological Process	GO:0050727	regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:68714
Biological Process	GO:0106014	regulation of inflammatory response to wounding	IMP	J:284986
Biological Process	GO:0050796	regulation of insulin secretion	IMP	J:137920
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	ISO	J:164563
Biological Process	GO:0019233	sensory perception of pain	ISO	J:155856