GO Annotations Graph

• Symbol: Amelx
• Name: amelogenin, X-linked
• ID: MGI:88005

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IDA	J:240272
Molecular Function	GO:0008083	growth factor activity	IMP	J:143679
Molecular Function	GO:0046848	hydroxyapatite binding	IDA	J:143691
Molecular Function	GO:0042802	identical protein binding	IPI	J:240270
Molecular Function	GO:0042802	identical protein binding	IPI	J:143691
Molecular Function	GO:0042802	identical protein binding	IPI	J:154019
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IDA	J:206681
Molecular Function	GO:0005515	protein binding	IPI	J:143680
Molecular Function	GO:0005515	protein binding	IPI	J:83640
Molecular Function	GO:0005515	protein binding	IPI	J:51772
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:240272
Molecular Function	GO:0031402	sodium ion binding	IDA	J:240270
Molecular Function	GO:0031402	sodium ion binding	IDA	J:240272
Molecular Function	GO:0030345	structural constituent of tooth enamel	ISO	J:164563
Molecular Function	GO:0030345	structural constituent of tooth enamel	ISO	J:155856
Molecular Function	GO:0030345	structural constituent of tooth enamel	ISO	J:164563
Molecular Function	GO:0030345	structural constituent of tooth enamel	IBA	J:265628
Cellular Component	GO:0005604	basement membrane	IDA	J:139122
Cellular Component	GO:0009986	cell surface	IMP	J:143680
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:155856
Cellular Component	GO:0031012	extracellular matrix	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:240272
Cellular Component	GO:0099080	supramolecular complex	IDA	J:240270
Biological Process	GO:0097186	amelogenesis	IDA	J:306590
Biological Process	GO:0031214	biomineral tissue development	IEA	J:60000
Biological Process	GO:0007155	cell adhesion	IMP	J:143679
Biological Process	GO:0070166	enamel mineralization	IDA	J:306590
Biological Process	GO:0070166	enamel mineralization	IBA	J:265628
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IEP	J:143680
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:143679
Biological Process	GO:0007165	signal transduction	TAS	J:143680
Biological Process	GO:0034505	tooth mineralization	IMP	J:71126