GO Annotations Graph

• Symbol: Ang
• Name: angiogenin, ribonuclease, RNase A family, 5
• ID: MGI:88022

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0005507	copper ion binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0042277	peptide binding	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	IC	J:4504
Molecular Function	GO:0004540	RNA nuclease activity	ISO	J:164563
Molecular Function	GO:0004540	RNA nuclease activity	IBA	J:265628
Molecular Function	GO:0004540	RNA nuclease activity	IDA	J:4504
Molecular Function	GO:0004540	RNA nuclease activity	IDA	J:208392
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0004549	tRNA-specific ribonuclease activity	IDA	J:314967
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0032311	angiogenin-PRI complex	ISO	J:73065
Cellular Component	GO:0005604	basement membrane	ISO	J:164563
Cellular Component	GO:0005694	chromosome	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-211119
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0030426	growth cone	IDA	J:124714
Cellular Component	GO:0043025	neuronal cell body	IDA	J:124714
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0032431	activation of phospholipase A2 activity	ISO	J:164563
Biological Process	GO:0007202	activation of phospholipase C activity	ISO	J:164563
Biological Process	GO:0032148	activation of protein kinase B activity	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	ISO	J:73065
Biological Process	GO:0019731	antibacterial humoral response	ISO	J:164563
Biological Process	GO:0019731	antibacterial humoral response	IDA	J:82368
Biological Process	GO:0019731	antibacterial humoral response	IBA	J:265628
Biological Process	GO:0019732	antifungal humoral response	ISO	J:164563
Biological Process	GO:0019732	antifungal humoral response	IDA	J:82368
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	J:82368
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	ISO	J:164563
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0007417	central nervous system development	NAS	J:124714
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IDA	J:82368
Biological Process	GO:0050830	defense response to Gram-positive bacterium	ISO	J:164563
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IBA	J:265628
Biological Process	GO:0006651	diacylglycerol biosynthetic process	ISO	J:164563
Biological Process	GO:0045087	innate immune response	IDA	J:82368
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0017148	negative regulation of translation	IEA	J:60000
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:164563
Biological Process	GO:0009725	response to hormone	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0001878	response to yeast	IDA	J:82368
Biological Process	GO:0001878	response to yeast	ISO	J:164563
Biological Process	GO:0009303	rRNA transcription	ISO	J:164563
Biological Process	GO:0036417	tRNA destabilization	IDA	J:314967