GO Annotations Graph

• Symbol: Apex1
• Name: apurinic/apyrimidinic endonuclease 1
• ID: MGI:88042

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008408	3'-5' exonuclease activity	ISO	J:164563
Molecular Function	GO:0008296	3'-5'-DNA exonuclease activity	ISO	J:164563
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0052720	class II DNA-(apurinic or apyrimidinic site) endonuclease activity	ISO	J:164563
Molecular Function	GO:0003684	damaged DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0140431	DNA-(abasic site) binding	ISO	J:164563
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	ISO	J:164563
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	IBA	J:265628
Molecular Function	GO:0008311	double-stranded DNA 3'-5' DNA exonuclease activity	IBA	J:265628
Molecular Function	GO:0008309	double-stranded DNA exodeoxyribonuclease activity	ISO	J:164563
Molecular Function	GO:0003691	double-stranded telomeric DNA binding	ISO	J:164563
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0004519	endonuclease activity	IEA	J:72247
Molecular Function	GO:0004527	exonuclease activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	ISO	J:164563
Molecular Function	GO:0051059	NF-kappaB binding	ISO	J:155856
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0004518	nuclease activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	ISO	J:164563
Molecular Function	GO:0090580	phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands	ISO	J:164563
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	ISO	J:164563
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:0004521	RNA endonuclease activity	ISO	J:155856
Molecular Function	GO:0016890	site-specific endodeoxyribonuclease activity, specific for altered base	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:87555
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:87555
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:155856
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0006284	base-excision repair	ISO	J:164563
Biological Process	GO:0006284	base-excision repair	IBA	J:265628
Biological Process	GO:0045454	cell redox homeostasis	IDA	J:87555
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0006308	DNA catabolic process	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0080111	DNA demethylation	ISO	J:164563
Biological Process	GO:0006310	DNA recombination	IEA	J:60000
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0014912	negative regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043488	regulation of mRNA stability	ISO	J:164563
Biological Process	GO:0000723	telomere maintenance	ISO	J:164563
Biological Process	GO:0097698	telomere maintenance via base-excision repair	ISO	J:164563