GO Annotations Graph

• Symbol: Aplp2
• Name: amyloid beta precursor-like protein 2
• ID: MGI:88047

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0008201	heparin binding	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:154833
Molecular Function	GO:0005515	protein binding	IPI	J:143818
Molecular Function	GO:0005515	protein binding	IPI	J:35780
Molecular Function	GO:0005515	protein binding	IPI	J:103763
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0046914	transition metal ion binding	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0097444	spine apparatus	IDA	J:242215
Cellular Component	GO:0097444	spine apparatus	IDA	J:242215
Cellular Component	GO:0097444	spine apparatus	IMP	J:242215
Cellular Component	GO:0097444	spine apparatus	IDA	J:242215
Biological Process	GO:0007409	axonogenesis	IBA	J:265628
Biological Process	GO:0007417	central nervous system development	IBA	J:265628
Biological Process	GO:0008203	cholesterol metabolic process	IGI	J:126954
Biological Process	GO:0009790	embryo development	IGI	J:98108
Biological Process	GO:0030198	extracellular matrix organization	IGI	J:93306
Biological Process	GO:0030900	forebrain development	IGI	J:98108
Biological Process	GO:0030900	forebrain development	IGI	J:93306
Biological Process	GO:0006878	intracellular copper ion homeostasis	IMP	J:58021
Biological Process	GO:0007626	locomotory behavior	IGI	J:45851
Biological Process	GO:0007617	mating behavior	IGI	J:45851
Biological Process	GO:0030901	midbrain development	IGI	J:98108
Biological Process	GO:0050885	neuromuscular process controlling balance	IGI	J:45851
Biological Process	GO:0007176	regulation of epidermal growth factor-activated receptor activity	IGI	J:122380
Biological Process	GO:0043393	regulation of protein binding	IGI	J:126954
Biological Process	GO:0001967	suckling behavior	IGI	J:45851