GO Annotations Graph

• Symbol: Apoa1
• Name: apolipoprotein A-I
• ID: MGI:88049

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:155856
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0034191	apolipoprotein A-I receptor binding	ISO	J:164563
Molecular Function	GO:0034190	apolipoprotein receptor binding	ISO	J:164563
Molecular Function	GO:0045499	chemorepellent activity	ISO	J:164563
Molecular Function	GO:0015485	cholesterol binding	ISO	J:164563
Molecular Function	GO:0120020	cholesterol transfer activity	ISO	J:155856
Molecular Function	GO:0120020	cholesterol transfer activity	ISO	J:164563
Molecular Function	GO:0120020	cholesterol transfer activity	ISO	J:164563
Molecular Function	GO:0120020	cholesterol transfer activity	IDA	J:93331
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:164563
Molecular Function	GO:0008035	high-density lipoprotein particle binding	IDA	J:75455
Molecular Function	GO:0008035	high-density lipoprotein particle binding	IDA	J:121045
Molecular Function	GO:0070653	high-density lipoprotein particle receptor binding	ISO	J:164563
Molecular Function	GO:0070653	high-density lipoprotein particle receptor binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:19659
Molecular Function	GO:0042802	identical protein binding	IPI	J:75455
Molecular Function	GO:0055102	lipase inhibitor activity	ISO	J:155856
Molecular Function	GO:0008289	lipid binding	IDA	J:19659
Molecular Function	GO:0005319	lipid transporter activity	IDA	J:75455
Molecular Function	GO:0005319	lipid transporter activity	IMP	J:2109
Molecular Function	GO:0071813	lipoprotein particle binding	IDA	J:19659
Molecular Function	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	ISO	J:164563
Molecular Function	GO:0005543	phospholipid binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:150861
Molecular Function	GO:0005515	protein binding	IPI	J:193640
Molecular Function	GO:0005515	protein binding	IPI	J:104106
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2425403
Cellular Component	GO:0034365	discoidal high-density lipoprotein particle	ISO	J:155856
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2173779
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2425403
Cellular Component	GO:0005576	extracellular region	IDA	J:97550
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:55744
Cellular Component	GO:0005615	extracellular space	IDA	J:40819
Cellular Component	GO:0005615	extracellular space	IDA	J:1067
Cellular Component	GO:0005615	extracellular space	ISO	J:73065
Cellular Component	GO:0005615	extracellular space	IDA	J:7017
Cellular Component	GO:0005615	extracellular space	IDA	J:42816
Cellular Component	GO:0005615	extracellular space	IDA	J:22986
Cellular Component	GO:0005615	extracellular space	IDA	J:45898
Cellular Component	GO:0005615	extracellular space	IDA	J:75455
Cellular Component	GO:0005615	extracellular space	IDA	J:42632
Cellular Component	GO:0005615	extracellular space	IDA	J:121045
Cellular Component	GO:0005615	extracellular space	IDA	J:84572
Cellular Component	GO:0005615	extracellular space	IDA	J:22362
Cellular Component	GO:0034364	high-density lipoprotein particle	ISO	J:164563
Cellular Component	GO:0034364	high-density lipoprotein particle	ISO	J:155856
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	ISO	J:155856
Cellular Component	GO:0034362	low-density lipoprotein particle	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0034366	spherical high-density lipoprotein particle	ISO	J:164563
Cellular Component	GO:0034361	very-low-density lipoprotein particle	ISO	J:164563
Biological Process	GO:0030325	adrenal gland development	IMP	J:76988
Biological Process	GO:0031100	animal organ regeneration	ISO	J:155856
Biological Process	GO:0043534	blood vessel endothelial cell migration	IMP	J:118063
Biological Process	GO:0006695	cholesterol biosynthetic process	IMP	J:76988
Biological Process	GO:0033344	cholesterol efflux	ISO	J:164563
Biological Process	GO:0033344	cholesterol efflux	IDA	J:75455
Biological Process	GO:0033344	cholesterol efflux	IDA	J:93331
Biological Process	GO:0033344	cholesterol efflux	IDA	J:40819
Biological Process	GO:0033344	cholesterol efflux	IDA	J:85674
Biological Process	GO:0033344	cholesterol efflux	IMP	J:42816
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0070508	cholesterol import	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:22986
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:114205
Biological Process	GO:0008203	cholesterol metabolic process	IGI	J:100492
Biological Process	GO:0008203	cholesterol metabolic process	IGI	J:100492
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:55744
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:93658
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:43915
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:117480
Biological Process	GO:0030301	cholesterol transport	ISO	J:155856
Biological Process	GO:0030301	cholesterol transport	IMP	J:120501
Biological Process	GO:0030301	cholesterol transport	IDA	J:42632
Biological Process	GO:0030301	cholesterol transport	IMP	J:45898
Biological Process	GO:0030301	cholesterol transport	ISO	J:59668
Biological Process	GO:0001935	endothelial cell proliferation	IMP	J:118063
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0008211	glucocorticoid metabolic process	IMP	J:76988
Biological Process	GO:0034380	high-density lipoprotein particle assembly	ISO	J:164563
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0019915	lipid storage	IMP	J:76988
Biological Process	GO:0006869	lipid transport	IEA	J:72247
Biological Process	GO:0006869	lipid transport	IEA	J:60000
Biological Process	GO:0042158	lipoprotein biosynthetic process	IGI	J:121045
Biological Process	GO:0042158	lipoprotein biosynthetic process	IMP	J:105606
Biological Process	GO:0042157	lipoprotein metabolic process	IEA	J:72247
Biological Process	GO:0050919	negative chemotaxis	ISO	J:164563
Biological Process	GO:0060354	negative regulation of cell adhesion molecule production	ISO	J:164563
Biological Process	GO:0002719	negative regulation of cytokine production involved in immune response	ISO	J:164563
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0051346	negative regulation of hydrolase activity	IGI	J:100492
Biological Process	GO:0050728	negative regulation of inflammatory response	ISO	J:164563
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	ISO	J:164563
Biological Process	GO:0060192	negative regulation of lipase activity	ISO	J:155856
Biological Process	GO:0060761	negative regulation of response to cytokine stimulus	ISO	J:164563
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0018206	peptidyl-methionine modification	ISO	J:164563
Biological Process	GO:0006656	phosphatidylcholine biosynthetic process	ISO	J:164563
Biological Process	GO:0046470	phosphatidylcholine metabolic process	IBA	J:265628
Biological Process	GO:0033700	phospholipid efflux	ISO	J:164563
Biological Process	GO:0055091	phospholipid homeostasis	ISO	J:164563
Biological Process	GO:0006644	phospholipid metabolic process	IMP	J:114205
Biological Process	GO:0015914	phospholipid transport	ISO	J:155856
Biological Process	GO:0010875	positive regulation of cholesterol efflux	ISO	J:164563
Biological Process	GO:0090205	positive regulation of cholesterol metabolic process	ISO	J:164563
Biological Process	GO:1905920	positive regulation of CoA-transferase activity	ISO	J:164563
Biological Process	GO:0051345	positive regulation of hydrolase activity	ISO	J:164563
Biological Process	GO:0050766	positive regulation of phagocytosis	ISO	J:164563
Biological Process	GO:1902995	positive regulation of phospholipid efflux	ISO	J:164563
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0051347	positive regulation of transferase activity	IMP	J:105606
Biological Process	GO:0018158	protein oxidation	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction	ISO	J:164563
Biological Process	GO:0030300	regulation of intestinal cholesterol absorption	IBA	J:265628
Biological Process	GO:0030300	regulation of intestinal cholesterol absorption	IDA	J:55595
Biological Process	GO:0001932	regulation of protein phosphorylation	IDA	J:85674
Biological Process	GO:0043691	reverse cholesterol transport	ISO	J:164563
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000
Biological Process	GO:0070328	triglyceride homeostasis	ISO	J:164563
Biological Process	GO:0051180	vitamin transport	ISO	J:164563