GO Annotations Graph

• Symbol: Apoa2
• Name: apolipoprotein A-II
• ID: MGI:88050

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0034190	apolipoprotein receptor binding	ISO	J:164563
Molecular Function	GO:0034190	apolipoprotein receptor binding	IBA	J:265628
Molecular Function	GO:0015485	cholesterol binding	ISO	J:164563
Molecular Function	GO:0015485	cholesterol binding	IBA	J:265628
Molecular Function	GO:0120020	cholesterol transfer activity	ISO	J:164563
Molecular Function	GO:0120020	cholesterol transfer activity	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0031072	heat shock protein binding	ISO	J:164563
Molecular Function	GO:0008035	high-density lipoprotein particle binding	IBA	J:265628
Molecular Function	GO:0008035	high-density lipoprotein particle binding	IMP	J:88979
Molecular Function	GO:0070653	high-density lipoprotein particle receptor binding	ISO	J:164563
Molecular Function	GO:0070653	high-density lipoprotein particle receptor binding	IBA	J:265628
Molecular Function	GO:0055102	lipase inhibitor activity	ISO	J:164563
Molecular Function	GO:0055102	lipase inhibitor activity	IBA	J:265628
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Molecular Function	GO:0005319	lipid transporter activity	ISO	J:164563
Molecular Function	GO:0031210	phosphatidylcholine binding	ISO	J:164563
Molecular Function	GO:0031210	phosphatidylcholine binding	IBA	J:265628
Molecular Function	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	ISO	J:164563
Molecular Function	GO:0005543	phospholipid binding	ISO	J:164563
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Cellular Component	GO:0042627	chylomicron	ISO	J:164563
Cellular Component	GO:0042627	chylomicron	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2425403
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2425403
Cellular Component	GO:0005615	extracellular space	IDA	J:7017
Cellular Component	GO:0005615	extracellular space	IDA	J:40819
Cellular Component	GO:0005615	extracellular space	IDA	J:1067
Cellular Component	GO:0034364	high-density lipoprotein particle	ISO	J:164563
Cellular Component	GO:0034366	spherical high-density lipoprotein particle	ISO	J:164563
Cellular Component	GO:0034366	spherical high-density lipoprotein particle	IBA	J:265628
Cellular Component	GO:0034361	very-low-density lipoprotein particle	ISO	J:164563
Cellular Component	GO:0034361	very-low-density lipoprotein particle	IBA	J:265628
Biological Process	GO:0031100	animal organ regeneration	ISO	J:155856
Biological Process	GO:0033344	cholesterol efflux	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	IBA	J:265628
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:55745
Biological Process	GO:0042632	cholesterol homeostasis	IGI	J:55745
Biological Process	GO:0042632	cholesterol homeostasis	IDA	J:4733
Biological Process	GO:0008203	cholesterol metabolic process	IBA	J:265628
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:76988
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:55745
Biological Process	GO:0008203	cholesterol metabolic process	IGI	J:55745
Biological Process	GO:0030301	cholesterol transport	ISO	J:155856
Biological Process	GO:0030301	cholesterol transport	IBA	J:265628
Biological Process	GO:0046340	diacylglycerol catabolic process	ISO	J:164563
Biological Process	GO:0034380	high-density lipoprotein particle assembly	ISO	J:164563
Biological Process	GO:0034380	high-density lipoprotein particle assembly	IBA	J:265628
Biological Process	GO:0034384	high-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	IBA	J:265628
Biological Process	GO:0006869	lipid transport	IMP	J:88979
Biological Process	GO:0042157	lipoprotein metabolic process	IBA	J:265628
Biological Process	GO:0042157	lipoprotein metabolic process	IDA	J:22520
Biological Process	GO:0042157	lipoprotein metabolic process	IDA	J:39861
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	IBA	J:265628
Biological Process	GO:0060621	negative regulation of cholesterol import	ISO	J:164563
Biological Process	GO:0032375	negative regulation of cholesterol transport	ISO	J:164563
Biological Process	GO:0060695	negative regulation of cholesterol transporter activity	ISO	J:164563
Biological Process	GO:0002719	negative regulation of cytokine production involved in immune response	ISO	J:164563
Biological Process	GO:0060192	negative regulation of lipase activity	ISO	J:164563
Biological Process	GO:0060192	negative regulation of lipase activity	IBA	J:265628
Biological Process	GO:0060192	negative regulation of lipase activity	IMP	J:55745
Biological Process	GO:0050995	negative regulation of lipid catabolic process	ISO	J:164563
Biological Process	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0018206	peptidyl-methionine modification	ISO	J:164563
Biological Process	GO:0006656	phosphatidylcholine biosynthetic process	ISO	J:164563
Biological Process	GO:0009395	phospholipid catabolic process	ISO	J:164563
Biological Process	GO:0033700	phospholipid efflux	ISO	J:164563
Biological Process	GO:1905920	positive regulation of CoA-transferase activity	ISO	J:164563
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0050996	positive regulation of lipid catabolic process	ISO	J:164563
Biological Process	GO:0050766	positive regulation of phagocytosis	ISO	J:164563
Biological Process	GO:0018158	protein oxidation	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0030300	regulation of intestinal cholesterol absorption	IMP	J:37250
Biological Process	GO:0031647	regulation of protein stability	ISO	J:164563
Biological Process	GO:0009749	response to glucose	ISO	J:164563
Biological Process	GO:0043691	reverse cholesterol transport	ISO	J:164563
Biological Process	GO:0034370	triglyceride-rich lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0034370	triglyceride-rich lipoprotein particle remodeling	IBA	J:265628