GO Annotations Graph

• Symbol: Apoc3
• Name: apolipoprotein C-III
• ID: MGI:88055

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030234	enzyme regulator activity	ISO	J:164563
Molecular Function	GO:0070653	high-density lipoprotein particle receptor binding	ISO	J:164563
Molecular Function	GO:0070653	high-density lipoprotein particle receptor binding	IBA	J:265628
Molecular Function	GO:0055102	lipase inhibitor activity	ISO	J:164563
Molecular Function	GO:0055102	lipase inhibitor activity	IBA	J:265628
Molecular Function	GO:0008289	lipid binding	IEA	J:72247
Molecular Function	GO:0005543	phospholipid binding	ISO	J:164563
Molecular Function	GO:0005543	phospholipid binding	IBA	J:265628
Cellular Component	GO:0042627	chylomicron	ISO	J:164563
Cellular Component	GO:0042627	chylomicron	IBA	J:265628
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2425403
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-2425403
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	ISO	J:164563
Cellular Component	GO:0034363	intermediate-density lipoprotein particle	IBA	J:265628
Cellular Component	GO:0034366	spherical high-density lipoprotein particle	ISO	J:164563
Cellular Component	GO:0034366	spherical high-density lipoprotein particle	IBA	J:265628
Cellular Component	GO:0034361	very-low-density lipoprotein particle	ISO	J:164563
Cellular Component	GO:0034361	very-low-density lipoprotein particle	IBA	J:265628
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0033344	cholesterol efflux	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	ISO	J:164563
Biological Process	GO:0042632	cholesterol homeostasis	IBA	J:265628
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:21750
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:72320
Biological Process	GO:0008203	cholesterol metabolic process	IMP	J:34875
Biological Process	GO:0034382	chylomicron remnant clearance	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0016042	lipid catabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0006869	lipid transport	IEA	J:72247
Biological Process	GO:0006869	lipid transport	IEA	J:60000
Biological Process	GO:0042157	lipoprotein metabolic process	IEA	J:72247
Biological Process	GO:0042953	lipoprotein transport	ISO	J:155856
Biological Process	GO:0060621	negative regulation of cholesterol import	ISO	J:164563
Biological Process	GO:0045717	negative regulation of fatty acid biosynthetic process	ISO	J:164563
Biological Process	GO:0010987	negative regulation of high-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:0010987	negative regulation of high-density lipoprotein particle clearance	IBA	J:265628
Biological Process	GO:0050995	negative regulation of lipid catabolic process	ISO	J:164563
Biological Process	GO:0045833	negative regulation of lipid metabolic process	ISO	J:164563
Biological Process	GO:0051005	negative regulation of lipoprotein lipase activity	ISO	J:164563
Biological Process	GO:0051005	negative regulation of lipoprotein lipase activity	IBA	J:265628
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:0010989	negative regulation of low-density lipoprotein particle clearance	IBA	J:265628
Biological Process	GO:0090324	negative regulation of oxidative phosphorylation	ISO	J:155856
Biological Process	GO:0048261	negative regulation of receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0010897	negative regulation of triglyceride catabolic process	ISO	J:164563
Biological Process	GO:0010897	negative regulation of triglyceride catabolic process	IBA	J:265628
Biological Process	GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	ISO	J:164563
Biological Process	GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	IBA	J:265628
Biological Process	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	ISO	J:164563
Biological Process	GO:0033700	phospholipid efflux	ISO	J:164563
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	ISO	J:155856
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction	ISO	J:164563
Biological Process	GO:0043434	response to peptide hormone	ISO	J:155856
Biological Process	GO:0019433	triglyceride catabolic process	ISO	J:164563
Biological Process	GO:0019433	triglyceride catabolic process	IMP	J:72320
Biological Process	GO:0070328	triglyceride homeostasis	ISO	J:164563
Biological Process	GO:0070328	triglyceride homeostasis	IBA	J:265628
Biological Process	GO:0006641	triglyceride metabolic process	ISO	J:164563
Biological Process	GO:0006641	triglyceride metabolic process	IMP	J:21750
Biological Process	GO:0006641	triglyceride metabolic process	IMP	J:72320
Biological Process	GO:0006642	triglyceride mobilization	IMP	J:34875
Biological Process	GO:0006642	triglyceride mobilization	IMP	J:72104