Atf4 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Atf4
activating transcription factor 4
MGI:88096

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008140	cAMP response element binding protein binding	IDA	J:198492
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IGI	J:115876
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:210921
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:198492
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:198927
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:89403
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:137331
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:237331
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:237331
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:0140296	general transcription initiation factor binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0043522	leucine zipper domain binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:121664
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:121664
Molecular Function	GO:0005515	protein binding	IPI	J:113939
Molecular Function	GO:0005515	protein binding	IPI	J:45936
Molecular Function	GO:0005515	protein binding	IPI	J:198492
Molecular Function	GO:0005515	protein binding	IPI	J:2973
Molecular Function	GO:0005515	protein binding	IPI	J:100180
Molecular Function	GO:0005515	protein binding	IPI	J:89403
Molecular Function	GO:0005515	protein binding	IPI	J:88780
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:83554
Molecular Function	GO:0005515	protein binding	IPI	J:115876
Molecular Function	GO:0005515	protein binding	IPI	J:193213
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:88780
Molecular Function	GO:0005515	protein binding	IPI	J:237331
Molecular Function	GO:0046982	protein heterodimerization activity	IDA	J:198492
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:176743
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP	J:210921
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:237331
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:237331
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:83554
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:97566
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:237331
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:237331
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:1990590	ATF1-ATF4 transcription factor complex	ISO	J:164563
Cellular Component	GO:1990590	ATF1-ATF4 transcription factor complex	IDA	J:217287
Cellular Component	GO:1990590	ATF1-ATF4 transcription factor complex	IBA	J:265628
Cellular Component	GO:1990589	ATF4-CREB1 transcription factor complex	IDA	J:217287
Cellular Component	GO:1990589	ATF4-CREB1 transcription factor complex	ISO	J:164563
Cellular Component	GO:1990589	ATF4-CREB1 transcription factor complex	IBA	J:265628
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:1990617	CHOP-ATF4 complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:148804
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:88780
Cellular Component	GO:0005737	cytoplasm	IDA	J:193213
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0032590	dendrite membrane	ISO	J:155856
Cellular Component	GO:1990037	Lewy body core	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	ISO	J:164563
Cellular Component	GO:0034399	nuclear periphery	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9635380
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9644310
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9644330
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9653747
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9654760
Cellular Component	GO:0005634	nucleus	IDA	J:124910
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:148804
Cellular Component	GO:0005634	nucleus	IDA	J:89403
Cellular Component	GO:0005634	nucleus	NAS	J:217287
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:193213
Cellular Component	GO:0005634	nucleus	IDA	J:88780
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	NAS	J:124910
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IPI	J:217287
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IDA	J:237331
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:115876
Biological Process	GO:0030282	bone mineralization	IMP	J:89403
Biological Process	GO:0034198	cellular response to amino acid starvation	IDA	J:99455
Biological Process	GO:0034198	cellular response to amino acid starvation	IMP	J:137331
Biological Process	GO:0034198	cellular response to amino acid starvation	IMP	J:124910
Biological Process	GO:1903351	cellular response to dopamine	ISO	J:164563
Biological Process	GO:0042149	cellular response to glucose starvation	ISO	J:164563
Biological Process	GO:1990253	cellular response to leucine starvation	ISO	J:121664
Biological Process	GO:1990253	cellular response to leucine starvation	IDA	J:121664
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:137331
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:176743
Biological Process	GO:0007623	circadian rhythm	IEP	J:176743
Biological Process	GO:0035162	embryonic hemopoiesis	IMP	J:74479
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA	J:198492
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	ISO	J:155856
Biological Process	GO:0006094	gluconeogenesis	IDA	J:76767
Biological Process	GO:0140468	HRI-mediated signaling	ISO	J:164563
Biological Process	GO:0140467	integrated stress response signaling	IMP	J:137331
Biological Process	GO:0140467	integrated stress response signaling	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:237331
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:237331
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:237331
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:167725
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA	J:198492
Biological Process	GO:0070982	L-asparagine metabolic process	ISO	J:164563
Biological Process	GO:0070309	lens fiber cell morphogenesis	IMP	J:74479
Biological Process	GO:0070309	lens fiber cell morphogenesis	IMP	J:56007
Biological Process	GO:0070309	lens fiber cell morphogenesis	IMP	J:62578
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	IDA	J:99455
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:249904
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death	ISO	J:155856
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death	ISO	J:164563
Biological Process	GO:0043267	negative regulation of potassium ion transport	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:85101
Biological Process	GO:0036499	PERK-mediated unfolded protein response	IMP	J:124910
Biological Process	GO:0036499	PERK-mediated unfolded protein response	IDA	J:137331
Biological Process	GO:0070169	positive regulation of biomineral tissue development	IMP	J:237331
Biological Process	GO:0070169	positive regulation of biomineral tissue development	IMP	J:237331
Biological Process	GO:0070169	positive regulation of biomineral tissue development	IMP	J:237331
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:176743
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:124910
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:237331
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:237331
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	IMP	J:167725
Biological Process	GO:2000120	positive regulation of sodium-dependent phosphate transport	IMP	J:237331
Biological Process	GO:2000120	positive regulation of sodium-dependent phosphate transport	IMP	J:237331
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:217287
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:62578
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:198927
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:89403
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:137331
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:210921
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:121664
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:97566
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:237331
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:83554
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:115876
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:237331
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:237331
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IMP	J:217287
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IMP	J:186974
Biological Process	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ISO	J:155856
Biological Process	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ISO	J:164563
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	IMP	J:237331
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	IMP	J:237331
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	IMP	J:237331
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:167725
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:189996
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:76767
Biological Process	GO:0045667	regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0045667	regulation of osteoblast differentiation	IMP	J:89403
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:85101
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:217287
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:83554
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:167725
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:99455
Biological Process	GO:0031667	response to nutrient levels	ISO	J:164563
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0006366	transcription by RNA polymerase II	IGI	J:97566

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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