GO Annotations Graph

• Symbol: Atp2b4
• Name: ATPase, Ca++ transporting, plasma membrane 4
• ID: MGI:88111

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0016887	ATP hydrolysis activity	IEA	J:72247
Molecular Function	GO:0015085	calcium ion transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0050998	nitric-oxide synthase binding	ISO	J:164563
Molecular Function	GO:0036487	nitric-oxide synthase inhibitor activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:72247
Molecular Function	GO:0005388	P-type calcium transporter activity	ISO	J:164563
Molecular Function	GO:0005388	P-type calcium transporter activity	ISO	J:155856
Molecular Function	GO:0005388	P-type calcium transporter activity	IBA	J:265628
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0030165	PDZ domain binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:256009
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0030346	protein phosphatase 2B binding	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	IPI	J:198910
Molecular Function	GO:0017080	sodium channel regulator activity	IMP	J:198910
Molecular Function	GO:0005215	transporter activity	IEA	J:72247
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005929	cilium	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0031514	motile cilium	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	J:84257
Cellular Component	GO:0048787	presynaptic active zone membrane	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:198910
Cellular Component	GO:0042383	sarcolemma	IDA	J:149624
Cellular Component	GO:0036126	sperm flagellum	IDA	J:121031
Cellular Component	GO:0097228	sperm principal piece	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	ISO	J:164563
Cellular Component	GO:0030315	T-tubule	IDA	J:149624
Cellular Component	GO:0030018	Z disc	ISO	J:164563
Biological Process	GO:1901660	calcium ion export	ISO	J:155856
Biological Process	GO:1901660	calcium ion export	ISO	J:164563
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	ISO	J:155856
Biological Process	GO:0006816	calcium ion transport	TAS	J:84257
Biological Process	GO:1905145	cellular response to acetylcholine	IMP	J:119880
Biological Process	GO:0071872	cellular response to epinephrine stimulus	ISO	J:164563
Biological Process	GO:0030317	flagellated sperm motility	IMP	J:121031
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:121031
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0140199	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	IMP	J:279971
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:1900082	negative regulation of arginine catabolic process	ISO	J:164563
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	IMP	J:279971
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	IMP	J:279971
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	ISO	J:164563
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	ISO	J:155856
Biological Process	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	IMP	J:149624
Biological Process	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	ISO	J:164563
Biological Process	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus	ISO	J:164563
Biological Process	GO:1903249	negative regulation of citrulline biosynthetic process	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:279971
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:279971
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	ISO	J:164563
Biological Process	GO:0010751	negative regulation of nitric oxide mediated signal transduction	ISO	J:164563
Biological Process	GO:0051001	negative regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation	NAS	J:198910
Biological Process	GO:0098736	negative regulation of the force of heart contraction	ISO	J:164563
Biological Process	GO:2000481	positive regulation of cAMP-dependent protein kinase activity	ISO	J:164563
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:1902806	regulation of cell cycle G1/S phase transition	ISO	J:164563
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	IBA	J:265628
Biological Process	GO:1902305	regulation of sodium ion transmembrane transport	IC	J:198910
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0051599	response to hydrostatic pressure	ISO	J:164563
Biological Process	GO:0014832	urinary bladder smooth muscle contraction	IMP	J:119880