GO Annotations Graph

• Symbol: Bcl2l1
• Name: BCL2-like 1
• ID: MGI:88139

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051400	BH domain binding	ISO	J:155856
Molecular Function	GO:0051434	BH3 domain binding	ISO	J:164563
Molecular Function	GO:0051434	BH3 domain binding	ISO	J:164563
Molecular Function	GO:0030276	clathrin binding	ISO	J:155856
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO	J:155856
Molecular Function	GO:0051020	GTPase binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:193499
Molecular Function	GO:0005515	protein binding	IPI	J:173139
Molecular Function	GO:0005515	protein binding	IPI	J:287050
Molecular Function	GO:0005515	protein binding	IPI	J:133563
Molecular Function	GO:0005515	protein binding	IPI	J:235310
Molecular Function	GO:0005515	protein binding	IPI	J:42326
Molecular Function	GO:0005515	protein binding	IPI	J:186336
Molecular Function	GO:0005515	protein binding	IPI	J:230059
Molecular Function	GO:0005515	protein binding	IPI	J:78230
Molecular Function	GO:0005515	protein binding	IPI	J:101198
Molecular Function	GO:0005515	protein binding	IPI	J:36730
Molecular Function	GO:0005515	protein binding	IPI	J:42326
Molecular Function	GO:0005515	protein binding	IPI	J:78230
Molecular Function	GO:0005515	protein binding	IPI	J:186336
Molecular Function	GO:0005515	protein binding	IPI	J:78583
Molecular Function	GO:0046982	protein heterodimerization activity	IBA	J:265628
Molecular Function	GO:0042803	protein homodimerization activity	IBA	J:265628
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Cellular Component	GO:0097136	Bcl-2 family protein complex	ISO	J:164563
Cellular Component	GO:0097136	Bcl-2 family protein complex	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:76215
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:230059
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:66494
Cellular Component	GO:0016020	membrane	IDA	J:230059
Cellular Component	GO:0005740	mitochondrial envelope	ISO	J:155856
Cellular Component	GO:0005743	mitochondrial inner membrane	IEA	J:60000
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:155856
Cellular Component	GO:0031966	mitochondrial membrane	IDA	J:76215
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:155856
Cellular Component	GO:0005741	mitochondrial outer membrane	ISO	J:164563
Cellular Component	GO:0005741	mitochondrial outer membrane	IBA	J:265628
Cellular Component	GO:0005741	mitochondrial outer membrane	IDA	J:204025
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:186336
Cellular Component	GO:0005739	mitochondrion	IDA	J:20957
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:85083
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0097143	PUMA-BCL-xl complex	ISO	J:164563
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IMP	J:63161
Biological Process	GO:0006915	apoptotic process	IMP	J:63161
Biological Process	GO:0006915	apoptotic process	IMP	J:63161
Biological Process	GO:0071839	apoptotic process in bone marrow cell	IMP	J:59317
Biological Process	GO:0071312	cellular response to alkaloid	IDA	J:93470
Biological Process	GO:0071230	cellular response to amino acid stimulus	IMP	J:93470
Biological Process	GO:0071480	cellular response to gamma radiation	IMP	J:93470
Biological Process	GO:0051607	defense response to virus	ISO	J:164563
Biological Process	GO:0097048	dendritic cell apoptotic process	IDA	J:118686
Biological Process	GO:0044565	dendritic cell proliferation	IDA	J:118686
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IMP	J:63161
Biological Process	GO:0050673	epithelial cell proliferation	IDA	J:40808
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IBA	J:265628
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:78230
Biological Process	GO:0009566	fertilization	IGI	J:63161
Biological Process	GO:0007281	germ cell development	IGI	J:63161
Biological Process	GO:0007281	germ cell development	IMP	J:63161
Biological Process	GO:0097284	hepatocyte apoptotic process	IMP	J:59317
Biological Process	GO:0001701	in utero embryonic development	IMP	J:59317
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IBA	J:265628
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:86000
Biological Process	GO:0008584	male gonad development	IMP	J:63161
Biological Process	GO:0070584	mitochondrion morphogenesis	IGI	J:186336
Biological Process	GO:2000811	negative regulation of anoikis	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IGI	J:35335
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:86000
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:28194
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:51799
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:63161
Biological Process	GO:0043066	negative regulation of apoptotic process	IDA	J:74669
Biological Process	GO:2000669	negative regulation of dendritic cell apoptotic process	IDA	J:118686
Biological Process	GO:0051093	negative regulation of developmental process	IMP	J:63161
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1900118	negative regulation of execution phase of apoptosis	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:230059
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO	J:164563
Biological Process	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:66953
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IDA	J:32153
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IDA	J:25204
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IDA	J:93470
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IGI	J:39573
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IGI	J:66953
Biological Process	GO:1903077	negative regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	ISO	J:164563
Biological Process	GO:2000242	negative regulation of reproductive process	IMP	J:63161
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:39573
Biological Process	GO:0051402	neuron apoptotic process	IDA	J:32153
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:59317
Biological Process	GO:0051402	neuron apoptotic process	IDA	J:25204
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:59317
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:66953
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:66953
Biological Process	GO:0001541	ovarian follicle development	ISO	J:155856
Biological Process	GO:0001541	ovarian follicle development	IMP	J:63161
Biological Process	GO:0001541	ovarian follicle development	IGI	J:63161
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	ISO	J:155856
Biological Process	GO:0032946	positive regulation of mononuclear cell proliferation	IDA	J:118686
Biological Process	GO:2000809	positive regulation of synaptic vesicle clustering	ISO	J:155856
Biological Process	GO:1900244	positive regulation of synaptic vesicle endocytosis	ISO	J:155856
Biological Process	GO:2000302	positive regulation of synaptic vesicle exocytosis	ISO	J:155856
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0032465	regulation of cytokinesis	ISO	J:164563
Biological Process	GO:0040008	regulation of growth	IMP	J:63161
Biological Process	GO:1900452	regulation of long-term synaptic depression	ISO	J:155856
Biological Process	GO:0046902	regulation of mitochondrial membrane permeability	ISO	J:164563
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	ISO	J:164563
Biological Process	GO:0001836	release of cytochrome c from mitochondria	ISO	J:164563
Biological Process	GO:0001836	release of cytochrome c from mitochondria	IGI	J:114403
Biological Process	GO:0046898	response to cycloheximide	IDA	J:40808
Biological Process	GO:0034097	response to cytokine	ISO	J:40789
Biological Process	GO:0002931	response to ischemia	ISO	J:155856
Biological Process	GO:0009314	response to radiation	IMP	J:86000
Biological Process	GO:0009615	response to virus	IDA	J:93470
Biological Process	GO:0007283	spermatogenesis	IGI	J:63161
Biological Process	GO:0019050	suppression by virus of host apoptotic process	ISO	J:93470
Biological Process	GO:0036466	synaptic vesicle recycling via endosome	ISO	J:155856