GO Annotations Graph

• Symbol: Bcl3
• Name: B cell leukemia/lymphoma 3
• ID: MGI:88140

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IBA	J:265628
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:108769
Molecular Function	GO:0005515	protein binding	IPI	J:163064
Molecular Function	GO:0005515	protein binding	IPI	J:121604
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	IDA	J:107516
Molecular Function	GO:0003714	transcription corepressor activity	ISO	J:164563
Cellular Component	GO:0032996	Bcl3-Bcl10 complex	ISO	J:164563
Cellular Component	GO:0033257	Bcl3/NF-kappaB2 complex	ISO	J:164563
Cellular Component	GO:0033257	Bcl3/NF-kappaB2 complex	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0019730	antimicrobial humoral response	IMP	J:38092
Biological Process	GO:0042742	defense response to bacterium	IMP	J:38092
Biological Process	GO:0042832	defense response to protozoan	IMP	J:38092
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0030198	extracellular matrix organization	IMP	J:112111
Biological Process	GO:0002268	follicular dendritic cell differentiation	IMP	J:112111
Biological Process	GO:0002467	germinal center formation	IMP	J:38092
Biological Process	GO:0002467	germinal center formation	IMP	J:112111
Biological Process	GO:0002467	germinal center formation	IMP	J:39747
Biological Process	GO:0002455	humoral immune response mediated by circulating immunoglobulin	IMP	J:38092
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO	J:73065
Biological Process	GO:0002315	marginal zone B cell differentiation	IMP	J:38092
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0032717	negative regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0070233	negative regulation of T cell apoptotic process	IGI	J:111822
Biological Process	GO:0070233	negative regulation of T cell apoptotic process	IMP	J:111822
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:94987
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0032733	positive regulation of interleukin-10 production	IMP	J:94987
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:107516
Biological Process	GO:0045727	positive regulation of translation	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:110058
Biological Process	GO:0006606	protein import into nucleus	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0010225	response to UV-C	ISO	J:164563
Biological Process	GO:0009615	response to virus	ISO	J:164563
Biological Process	GO:0048536	spleen development	IMP	J:112111
Biological Process	GO:0070231	T cell apoptotic process	IGI	J:111822
Biological Process	GO:0070231	T cell apoptotic process	IMP	J:111822
Biological Process	GO:0042088	T-helper 1 type immune response	IMP	J:38092
Biological Process	GO:0045064	T-helper 2 cell differentiation	IMP	J:107516
Biological Process	GO:0032609	type II interferon production	IMP	J:110058