GO Annotations Graph

• Symbol: Btk
• Name: Bruton agammaglobulinemia tyrosine kinase
• ID: MGI:88216

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	ISO	J:164563
Molecular Function	GO:0016004	phospholipase activator activity	ISO	J:164563
Molecular Function	GO:0043274	phospholipase binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:171920
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:171920
Molecular Function	GO:0005515	protein binding	IPI	J:95172
Molecular Function	GO:0005515	protein binding	IPI	J:91443
Molecular Function	GO:0005515	protein binding	IPI	J:65127
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	EXP	J:266154
Molecular Function	GO:0004713	protein tyrosine kinase activity	EXP	J:266149
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:331919
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:65127
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:62510
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:65127
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:88793
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2730850
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9607032
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9607033
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:65127
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0002344	B cell affinity maturation	IMP	J:17954
Biological Process	GO:0050853	B cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050853	B cell receptor signaling pathway	IBA	J:265628
Biological Process	GO:0048469	cell maturation	IMP	J:87650
Biological Process	GO:0048469	cell maturation	IMP	J:87650
Biological Process	GO:0098761	cellular response to interleukin-7	IMP	J:17954
Biological Process	GO:0071226	cellular response to molecule of fungal origin	ISO	J:155856
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:155856
Biological Process	GO:1990959	eosinophil homeostasis	ISO	J:155856
Biological Process	GO:0002553	histamine secretion by mast cell	ISO	J:155856
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:86551
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0061516	monocyte proliferation	ISO	J:155856
Biological Process	GO:0050869	negative regulation of B cell activation	ISO	J:155856
Biological Process	GO:0030889	negative regulation of B cell proliferation	IMP	J:17954
Biological Process	GO:0001818	negative regulation of cytokine production	IMP	J:199894
Biological Process	GO:0032693	negative regulation of interleukin-10 production	ISO	J:155856
Biological Process	GO:0070664	negative regulation of leukocyte proliferation	ISO	J:155856
Biological Process	GO:0001780	neutrophil homeostasis	ISO	J:155856
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:62510
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0030890	positive regulation of B cell proliferation	ISO	J:155856
Biological Process	GO:0002639	positive regulation of immunoglobulin production	ISO	J:155856
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0150153	positive regulation of interleukin-17A production	ISO	J:155856
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	IDA	J:331919
Biological Process	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	ISO	J:164563
Biological Process	GO:0050766	positive regulation of phagocytosis	ISO	J:155856
Biological Process	GO:1901647	positive regulation of synoviocyte proliferation	ISO	J:155856
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0001812	positive regulation of type I hypersensitivity	ISO	J:155856
Biological Process	GO:0001805	positive regulation of type III hypersensitivity	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:79133
Biological Process	GO:0030167	proteoglycan catabolic process	ISO	J:155856
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:155856
Biological Process	GO:0010033	response to organic substance	ISO	J:155856
Biological Process	GO:0050852	T cell receptor signaling pathway	IBA	J:265628