GO Annotations Graph

• Symbol: C2
• Name: complement C2
• ID: MGI:88226

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0004252	serine-type endopeptidase activity	IEA	J:72247
Molecular Function	GO:0004252	serine-type endopeptidase activity	IEA	J:72245
Molecular Function	GO:0008236	serine-type peptidase activity	IEA	J:60000
Cellular Component	GO:0005601	classical-complement-pathway C3/C5 convertase complex	ISO	J:164563
Cellular Component	GO:0005601	classical-complement-pathway C3/C5 convertase complex	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:72247
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005886	plasma membrane	NAS	J:320301
Cellular Component	GO:0005886	plasma membrane	NAS	J:320299
Biological Process	GO:0006956	complement activation	ISO	J:164563
Biological Process	GO:0006956	complement activation	ISO	J:164563
Biological Process	GO:0006958	complement activation, classical pathway	IEA	J:60000
Biological Process	GO:0006958	complement activation, classical pathway	IEA	J:72247
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:2000427	positive regulation of apoptotic cell clearance	ISO	J:164563
Biological Process	GO:0050778	positive regulation of immune response	NAS	J:320297
Biological Process	GO:0050778	positive regulation of immune response	NAS	J:320300
Biological Process	GO:1903028	positive regulation of opsonization	NAS	J:320297
Biological Process	GO:1903028	positive regulation of opsonization	NAS	J:320300
Biological Process	GO:0006508	proteolysis	IEA	J:72247
Biological Process	GO:0006508	proteolysis	IEA	J:60000