GO Annotations Graph

• Symbol: C3
• Name: complement component 3
• ID: MGI:88227

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031715	C5L2 anaphylatoxin chemotactic receptor binding	ISO	J:164563
Molecular Function	GO:0004866	endopeptidase inhibitor activity	IEA	J:72247
Molecular Function	GO:0008289	lipid binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:242465
Molecular Function	GO:0005515	protein binding	IPI	J:242465
Molecular Function	GO:0005515	protein binding	IPI	J:105012
Molecular Function	GO:0005515	protein binding	IPI	J:73128
Cellular Component	GO:0009986	cell surface	IDA	J:218542
Cellular Component	GO:0005576	extracellular region	IDA	J:149558
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	NAS	J:320294
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:131526
Cellular Component	GO:0005886	plasma membrane	NAS	J:320294
Cellular Component	GO:0005886	plasma membrane	NAS	J:320299
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	IDA	J:242465
Cellular Component	GO:1905370	serine-type endopeptidase complex	ISO	J:164563
Biological Process	GO:0097242	amyloid-beta clearance	IGI	J:242546
Biological Process	GO:0097242	amyloid-beta clearance	IMP	J:183868
Biological Process	GO:0007596	blood coagulation	ISO	J:155856
Biological Process	GO:1905114	cell surface receptor signaling pathway involved in cell-cell signaling	IMP	J:263413
Biological Process	GO:0006956	complement activation	ISO	J:164563
Biological Process	GO:0006956	complement activation	NAS	J:320126
Biological Process	GO:0006956	complement activation	NAS	J:320294
Biological Process	GO:0006956	complement activation	ISO	J:164563
Biological Process	GO:0006956	complement activation	ISO	J:155856
Biological Process	GO:0006956	complement activation	IBA	J:265628
Biological Process	GO:0006956	complement activation	IMP	J:218542
Biological Process	GO:0006956	complement activation	IDA	J:145047
Biological Process	GO:0006957	complement activation, alternative pathway	IEA	J:60000
Biological Process	GO:0006958	complement activation, classical pathway	IEA	J:60000
Biological Process	GO:0097278	complement-dependent cytotoxicity	IMP	J:218542
Biological Process	GO:0150062	complement-mediated synapse pruning	IMP	J:137589
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:72247
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0016322	neuron remodeling	IMP	J:137589
Biological Process	GO:0008228	opsonization	ISO	J:164563
Biological Process	GO:0035846	oviduct epithelium development	IGI	J:280694
Biological Process	GO:0001970	positive regulation of activation of membrane attack complex	IMP	J:157443
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:106063
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:157443
Biological Process	GO:2000427	positive regulation of apoptotic cell clearance	ISO	J:164563
Biological Process	GO:0044533	positive regulation of apoptotic process in another organism	NAS	J:320295
Biological Process	GO:0048639	positive regulation of developmental growth	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0010828	positive regulation of glucose transmembrane transport	ISO	J:164563
Biological Process	GO:0050778	positive regulation of immune response	NAS	J:320294
Biological Process	GO:0050778	positive regulation of immune response	NAS	J:320297
Biological Process	GO:0050778	positive regulation of immune response	NAS	J:320126
Biological Process	GO:0050778	positive regulation of immune response	NAS	J:320298
Biological Process	GO:0010884	positive regulation of lipid storage	ISO	J:164563
Biological Process	GO:1903028	positive regulation of opsonization	ISO	J:164563
Biological Process	GO:1903028	positive regulation of opsonization	NAS	J:320126
Biological Process	GO:1903028	positive regulation of opsonization	NAS	J:320294
Biological Process	GO:1903028	positive regulation of opsonization	NAS	J:320297
Biological Process	GO:0050766	positive regulation of phagocytosis	NAS	J:320296
Biological Process	GO:0050766	positive regulation of phagocytosis	IMP	J:75709
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	IMP	J:263413
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	IMP	J:183868
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment	IGI	J:242546
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	IMP	J:183868
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	IGI	J:242546
Biological Process	GO:0001798	positive regulation of type IIa hypersensitivity	IMP	J:75709
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0030449	regulation of complement activation	ISO	J:164563
Biological Process	GO:0030451	regulation of complement activation, alternative pathway	ISO	J:164563
Biological Process	GO:0010866	regulation of triglyceride biosynthetic process	ISO	J:164563
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0060041	retina development in camera-type eye	IGI	J:240426
Biological Process	GO:0035886	vascular associated smooth muscle cell differentiation	IGI	J:240426
Biological Process	GO:0150064	vertebrate eye-specific patterning	IMP	J:137589