GO Annotations Graph

• Symbol: C5ar1
• Name: complement component 5a receptor 1
• ID: MGI:88232

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001856	complement component C5a binding	ISO	J:155856
Molecular Function	GO:0004878	complement component C5a receptor activity	ISO	J:164563
Molecular Function	GO:0004878	complement component C5a receptor activity	ISO	J:155856
Molecular Function	GO:0004878	complement component C5a receptor activity	IBA	J:265628
Molecular Function	GO:0004878	complement component C5a receptor activity	IDA	J:2871
Molecular Function	GO:0004875	complement receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	ISO	J:164563
Molecular Function	GO:0004930	G protein-coupled receptor activity	IBA	J:265628
Cellular Component	GO:0045177	apical part of cell	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0097242	amyloid-beta clearance	IGI	J:151661
Biological Process	GO:0006915	apoptotic process	ISO	J:155856
Biological Process	GO:0048143	astrocyte activation	IGI	J:151661
Biological Process	GO:0021534	cell proliferation in hindbrain	ISO	J:155856
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0006935	chemotaxis	IEA	J:72247
Biological Process	GO:0050890	cognition	IGI	J:151661
Biological Process	GO:0038178	complement component C5a signaling pathway	ISO	J:164563
Biological Process	GO:0002430	complement receptor mediated signaling pathway	IBA	J:265628
Biological Process	GO:0050830	defense response to Gram-positive bacterium	IMP	J:140680
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0001774	microglial cell activation	IGI	J:151661
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0030593	neutrophil chemotaxis	IMP	J:140680
Biological Process	GO:0030593	neutrophil chemotaxis	IMP	J:140680
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:106063
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IBA	J:265628
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	IMP	J:106063
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	IMP	J:106063
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	IMP	J:106063
Biological Process	GO:0099172	presynapse organization	IGI	J:151661
Biological Process	GO:1902947	regulation of tau-protein kinase activity	IGI	J:151661
Biological Process	GO:0032494	response to peptidoglycan	IMP	J:140680
Biological Process	GO:0007165	signal transduction	IEA	J:60000