GO Annotations Graph

• Symbol: S100a8
• Name: S100 calcium binding protein A8 (calgranulin A)
• ID: MGI:88244

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016209	antioxidant activity	IEA	J:60000
Molecular Function	GO:0050544	arachidonic acid binding	IEA	J:72247
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008017	microtubule binding	IEA	J:72247
Molecular Function	GO:0050786	RAGE receptor binding	IEA	J:72247
Molecular Function	GO:0035662	Toll-like receptor 4 binding	IEA	J:72247
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0045111	intermediate filament cytoskeleton	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0014002	astrocyte development	IGI	J:188377
Biological Process	GO:0035425	autocrine signaling	ISO	J:155856
Biological Process	GO:0006914	autophagy	ISO	J:164563
Biological Process	GO:0006935	chemotaxis	IEA	J:60000
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:72247
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	ISO	J:164563
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	IBA	J:265628
Biological Process	GO:0070488	neutrophil aggregation	ISO	J:164563
Biological Process	GO:0070488	neutrophil aggregation	IBA	J:265628
Biological Process	GO:0030593	neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:0002790	peptide secretion	IDA	J:145634
Biological Process	GO:0002790	peptide secretion	IMP	J:145634
Biological Process	GO:0018119	peptidyl-cysteine S-nitrosylation	ISO	J:164563
Biological Process	GO:0050729	positive regulation of inflammatory response	ISO	J:164563
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0002793	positive regulation of peptide secretion	IMP	J:145634
Biological Process	GO:0002793	positive regulation of peptide secretion	IDA	J:145634
Biological Process	GO:0002793	positive regulation of peptide secretion	IDA	J:145634
Biological Process	GO:0002793	positive regulation of peptide secretion	IMP	J:145634
Biological Process	GO:0050727	regulation of inflammatory response	IEA	J:72247
Biological Process	GO:0032496	response to lipopolysaccharide	IBA	J:265628