GO Annotations Graph

• Symbol: Anxa2
• Name: annexin A2
• ID: MGI:88246

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0044730	bone sialoprotein binding	ISO	J:155856
Molecular Function	GO:0005262	calcium channel activity	IBA	J:265628
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	ISO	J:164563
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	IBA	J:265628
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:164563
Molecular Function	GO:0008092	cytoskeletal protein binding	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:164563
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:155856
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	IBA	J:265628
Molecular Function	GO:0001786	phosphatidylserine binding	IBA	J:265628
Molecular Function	GO:0019834	phospholipase A2 inhibitor activity	ISO	J:164563
Molecular Function	GO:0019834	phospholipase A2 inhibitor activity	IBA	J:265628
Molecular Function	GO:0004859	phospholipase inhibitor activity	IEA	J:72247
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0002020	protease binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:193813
Molecular Function	GO:0005515	protein binding	IPI	J:87169
Molecular Function	GO:0005515	protein binding	IPI	J:160150
Molecular Function	GO:0044548	S100 protein binding	ISO	J:164563
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:164563
Molecular Function	GO:0031267	small GTPase binding	ISO	J:155856
Molecular Function	GO:0046790	virion binding	IBA	J:265628
Cellular Component	GO:1990665	AnxA2-p11 complex	ISO	J:164563
Cellular Component	GO:0005604	basement membrane	IEA	J:60000
Cellular Component	GO:0016323	basolateral plasma membrane	IDA	J:189694
Cellular Component	GO:0005938	cell cortex	ISO	J:155856
Cellular Component	GO:0030054	cell junction	ISS	J:83590
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:149113
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0001533	cornified envelope	IDA	J:230728
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:91039
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5332993
Cellular Component	GO:0005829	cytosol	IDA	J:116472
Cellular Component	GO:0005769	early endosome	IDA	J:91039
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0031902	late endosome membrane	ISO	J:164563
Cellular Component	GO:0005811	lipid droplet	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0044354	macropinosome	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:198595
Cellular Component	GO:0016020	membrane	ISS	J:83590
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0035749	myelin sheath adaxonal region	IDA	J:159103
Cellular Component	GO:0016363	nuclear matrix	NAS	J:193813
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:1990667	PCSK9-AnxA2 complex	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:198595
Cellular Component	GO:0098797	plasma membrane protein complex	ISO	J:164563
Cellular Component	GO:0098797	plasma membrane protein complex	EXP	J:193813
Cellular Component	GO:0098797	plasma membrane protein complex	IPI	J:193813
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IPI	J:193813
Cellular Component	GO:0001726	ruffle	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IDA	J:87169
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	IDA	J:159103
Cellular Component	GO:0001725	stress fiber	ISS	J:83590
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Cellular Component	GO:0031982	vesicle	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IMP	J:87621
Biological Process	GO:0007589	body fluid secretion	ISO	J:155856
Biological Process	GO:0071229	cellular response to acid chemical	IDA	J:149113
Biological Process	GO:0030199	collagen fibril organization	IMP	J:87621
Biological Process	GO:0042730	fibrinolysis	IMP	J:87621
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	IDA	J:193813
Biological Process	GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process	IMP	J:189694
Biological Process	GO:0051099	positive regulation of binding	IMP	J:149113
Biological Process	GO:0045921	positive regulation of exocytosis	NAS	J:320055
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:1905581	positive regulation of low-density lipoprotein particle clearance	IMP	J:189694
Biological Process	GO:1905597	positive regulation of low-density lipoprotein particle receptor binding	IMP	J:189694
Biological Process	GO:1905599	positive regulation of low-density lipoprotein receptor activity	IMP	J:189694
Biological Process	GO:1905686	positive regulation of plasma membrane repair	NAS	J:320055
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0001921	positive regulation of receptor recycling	IMP	J:189694
Biological Process	GO:1905602	positive regulation of receptor-mediated endocytosis involved in cholesterol transport	IMP	J:189694
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:193813
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:155856
Biological Process	GO:0050767	regulation of neurogenesis	IDA	J:193813