GO Annotations Graph

• Symbol: Camk2a
• Name: calcium/calmodulin-dependent protein kinase II alpha
• ID: MGI:88256

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0009931	calcium-dependent protein serine/threonine kinase activity	IDA	J:240285
Molecular Function	GO:0005516	calmodulin binding	ISO	J:164563
Molecular Function	GO:0005516	calmodulin binding	IDA	J:240285
Molecular Function	GO:0005516	calmodulin binding	IBA	J:265628
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	IDA	J:240285
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	ISO	J:155856
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	ISO	J:164563
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	IBA	J:265628
Molecular Function	GO:0035254	glutamate receptor binding	IPI	J:119025
Molecular Function	GO:0032794	GTPase activating protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:63100
Molecular Function	GO:0005515	protein binding	IPI	J:249721
Molecular Function	GO:0005515	protein binding	IPI	J:208030
Molecular Function	GO:0005515	protein binding	IPI	J:197634
Molecular Function	GO:0005515	protein binding	IPI	J:182401
Molecular Function	GO:0005515	protein binding	IPI	J:119025
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:161179
Molecular Function	GO:0005515	protein binding	IPI	J:239596
Molecular Function	GO:0005515	protein binding	IPI	J:181943
Molecular Function	GO:0005515	protein binding	IPI	J:152628
Molecular Function	GO:0005515	protein binding	IPI	J:200304
Molecular Function	GO:0005515	protein binding	IPI	J:113949
Molecular Function	GO:0005515	protein binding	IPI	J:216588
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:136341
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:84257
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:189223
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005954	calcium- and calmodulin-dependent protein kinase complex	ISO	J:164563
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0032839	dendrite cytoplasm	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:164563
Cellular Component	GO:0099573	glutamatergic postsynaptic density	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:189223
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0099524	postsynaptic cytosol	ISO	J:155856
Cellular Component	GO:0099524	postsynaptic cytosol	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0099523	presynaptic cytosol	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:127397
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:127397
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:127397
Cellular Component	GO:0045202	synapse	IDA	J:314561
Biological Process	GO:0038166	angiotensin-activated signaling pathway	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	IMP	J:84257
Biological Process	GO:0099004	calmodulin dependent kinase signaling pathway	ISO	J:155856
Biological Process	GO:0035458	cellular response to interferon-beta	ISO	J:164563
Biological Process	GO:0071346	cellular response to type II interferon	ISO	J:164563
Biological Process	GO:0048813	dendrite morphogenesis	IMP	J:216588
Biological Process	GO:0060996	dendritic spine development	ISO	J:164563
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IMP	J:84257
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0051346	negative regulation of hydrolase activity	IMP	J:197634
Biological Process	GO:0098989	NMDA selective glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:240285
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:189223
Biological Process	GO:1990443	peptidyl-threonine autophosphorylation	ISO	J:164563
Biological Process	GO:1990443	peptidyl-threonine autophosphorylation	IMP	J:239596
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0051928	positive regulation of calcium ion transport	IMP	J:189223
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	IMP	J:189223
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0098970	postsynaptic neurotransmitter receptor diffusion trapping	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	IMP	J:84257
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:2000124	regulation of endocannabinoid signaling pathway	IMP	J:197634
Biological Process	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	IMP	J:189223
Biological Process	GO:2001222	regulation of neuron migration	ISO	J:164563
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	IMP	J:126092
Biological Process	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO	J:155856
Biological Process	GO:0046928	regulation of neurotransmitter secretion	IMP	J:82744
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	ISO	J:155856
Biological Process	GO:0099148	regulation of synaptic vesicle docking	IDA	J:127397
Biological Process	GO:0099148	regulation of synaptic vesicle docking	IDA	J:127397
Biological Process	GO:0099148	regulation of synaptic vesicle docking	IMP	J:127397
Biological Process	GO:0002931	response to ischemia	IMP	J:189223