GO Annotations Graph

• Symbol: Capn1
• Name: calpain 1
• ID: MGI:88263

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	ISO	J:155856
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IDA	J:124046
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	TAS	J:74966
Molecular Function	GO:0004198	calcium-dependent cysteine-type endopeptidase activity	ISO	J:125385
Molecular Function	GO:0008234	cysteine-type peptidase activity	IEA	J:60000
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:144029
Molecular Function	GO:0005515	protein binding	IPI	J:124046
Molecular Function	GO:0005515	protein binding	IPI	J:124046
Cellular Component	GO:0001533	cornified envelope	IDA	J:230728
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:204792
Cellular Component	GO:0005764	lysosome	IDA	J:204792
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:204792
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-8863416
Biological Process	GO:0070301	cellular response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0060056	mammary gland involution	IMP	J:204792
Biological Process	GO:0030837	negative regulation of actin filament polymerization	ISO	J:155856
Biological Process	GO:1901223	negative regulation of NIK/NF-kappaB signaling	ISO	J:155856
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:1903238	positive regulation of leukocyte tethering or rolling	ISO	J:155856
Biological Process	GO:0043117	positive regulation of vascular permeability	ISO	J:155856
Biological Process	GO:0016540	protein autoprocessing	ISO	J:155856
Biological Process	GO:0030163	protein catabolic process	ISO	J:155856
Biological Process	GO:0006508	proteolysis	ISO	J:155856
Biological Process	GO:0006508	proteolysis	NAS	J:320066
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IBA	J:265628
Biological Process	GO:0006508	proteolysis	IMP	J:204792
Biological Process	GO:0032801	receptor catabolic process	IDA	J:124046
Biological Process	GO:0050790	regulation of catalytic activity	ISO	J:164563
Biological Process	GO:1990776	response to angiotensin	ISO	J:155856
Biological Process	GO:0097264	self proteolysis	ISO	J:164563