GO Annotations Graph

• Symbol: Cbl
• Name: Casitas B-lineage lymphoma
• ID: MGI:88279

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0046875	ephrin receptor binding	ISO	J:164563
Molecular Function	GO:0046875	ephrin receptor binding	IPI	J:177152
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	ISO	J:155856
Molecular Function	GO:0001784	phosphotyrosine residue binding	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:46223
Molecular Function	GO:0005515	protein binding	IPI	J:206889
Molecular Function	GO:0005515	protein binding	IPI	J:227464
Molecular Function	GO:0005515	protein binding	IPI	J:230359
Molecular Function	GO:0005515	protein binding	IPI	J:239186
Molecular Function	GO:0005515	protein binding	IPI	J:200344
Molecular Function	GO:0005515	protein binding	IPI	J:193456
Molecular Function	GO:0005515	protein binding	IPI	J:206833
Molecular Function	GO:0005515	protein binding	IPI	J:46223
Molecular Function	GO:0005515	protein binding	IPI	J:156085
Molecular Function	GO:0005515	protein binding	IPI	J:35635
Molecular Function	GO:0005515	protein binding	IPI	J:35635
Molecular Function	GO:0005515	protein binding	IPI	J:107908
Molecular Function	GO:0005515	protein binding	IPI	J:76181
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IBA	J:265628
Molecular Function	GO:0017124	SH3 domain binding	IPI	J:46223
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:155856
Molecular Function	GO:0017124	SH3 domain binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:155856
Molecular Function	GO:0061630	ubiquitin protein ligase activity	TAS	Reactome:R-MMU-9763892
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IEA	J:72247
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005929	cilium	ISO	J:164563
Cellular Component	GO:0005929	cilium	IDA	J:281256
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680706
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9763891
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9763892
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9817994
Cellular Component	GO:0016600	flotillin complex	IDA	J:114794
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:281256
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0045121	membrane raft	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0007166	cell surface receptor signaling pathway	IEA	J:72247
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	IBA	J:265628
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	ISO	J:164563
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:155856
Biological Process	GO:0006513	protein monoubiquitination	ISO	J:155856
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:155856
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:2000583	regulation of platelet-derived growth factor receptor-alpha signaling pathway	IMP	J:281256
Biological Process	GO:0032487	regulation of Rap protein signal transduction	IMP	J:115703
Biological Process	GO:0023051	regulation of signaling	IEA	J:72247
Biological Process	GO:0046677	response to antibiotic	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563