Cacna1d GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
MGI:88293

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051393	alpha-actinin binding	ISO	J:164563
Molecular Function	GO:0030506	ankyrin binding	ISO	J:155856
Molecular Function	GO:0030506	ankyrin binding	IPI	J:185021
Molecular Function	GO:0005262	calcium channel activity	ISO	J:164563
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	ISO	J:155856
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	IDA	J:86180
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0030165	PDZ domain binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:119891
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:164563
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:155856
Molecular Function	GO:0099635	voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels	TAS	Reactome:R-MMU-9659489
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IMP	J:63515
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IDA	J:63515
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IDA	J:63515
Molecular Function	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential	ISO	J:164563
Molecular Function	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential	IMP	J:151611
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	IDA	J:63515
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	IDA	J:63515
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	IMP	J:63515
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	IDA	J:263450
Cellular Component	GO:0098683	cochlear hair cell ribbon synapse	IDA	J:263450
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0032590	dendrite membrane	ISO	J:155856
Cellular Component	GO:1990454	L-type voltage-gated calcium channel complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:185021
Cellular Component	GO:0005886	plasma membrane	IDA	J:186061
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-525831
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9659489
Cellular Component	GO:0005886	plasma membrane	IC	J:86180
Cellular Component	GO:0005886	plasma membrane	IDA	J:119891
Cellular Component	GO:0048787	presynaptic active zone membrane	IDA	J:263450
Cellular Component	GO:0048787	presynaptic active zone membrane	IDA	J:263450
Cellular Component	GO:0150001	primary dendrite	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0005891	voltage-gated calcium channel complex	ISO	J:164563
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IBA	J:265628
Cellular Component	GO:0005891	voltage-gated calcium channel complex	TAS	J:76458
Cellular Component	GO:0030018	Z disc	IDA	J:130245
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP	J:108922
Biological Process	GO:0070509	calcium ion import	ISO	J:164563
Biological Process	GO:0070509	calcium ion import	ISO	J:155856
Biological Process	GO:0098703	calcium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:99822
Biological Process	GO:0006816	calcium ion transport	ISO	J:155856
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:155856
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	ISO	J:164563
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:99822
Biological Process	GO:0086046	membrane depolarization during SA node cell action potential	ISO	J:164563
Biological Process	GO:0086046	membrane depolarization during SA node cell action potential	IMP	J:99822
Biological Process	GO:0030001	metal ion transport	ISO	J:155856
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	IDA	J:266464
Biological Process	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO	J:155856
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:164563
Biological Process	GO:0032793	positive regulation of CREB transcription factor activity	ISO	J:155856
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:1904181	positive regulation of membrane depolarization	ISO	J:155856
Biological Process	GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization	IMP	J:130245
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	ISO	J:164563
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	IMP	J:99822
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	IMP	J:130245
Biological Process	GO:1901016	regulation of potassium ion transmembrane transporter activity	IMP	J:130245
Biological Process	GO:0007605	sensory perception of sound	ISO	J:164563
Biological Process	GO:0007605	sensory perception of sound	IMP	J:117764
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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