GO Annotations Graph

• Symbol: Cd3e
• Name: CD3 antigen, epsilon polypeptide
• ID: MGI:88332

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:18500
Molecular Function	GO:0005515	protein binding	IPI	J:18500
Molecular Function	GO:0005515	protein binding	IPI	J:91455
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IBA	J:265628
Cellular Component	GO:0042105	alpha-beta T cell receptor complex	ISO	J:164563
Cellular Component	GO:0042105	alpha-beta T cell receptor complex	IBA	J:265628
Cellular Component	GO:0042105	alpha-beta T cell receptor complex	IDA	J:35279
Cellular Component	GO:0042105	alpha-beta T cell receptor complex	IDA	J:41170
Cellular Component	GO:0044297	cell body	IDA	J:123637
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0043197	dendritic spine	IDA	J:123637
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:92334
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:143981
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:27768
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:17350
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:53400
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:73065
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:163607
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:34311
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:98326
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:189787
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:157744
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:163829
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:145327
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:33466
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0001772	immunological synapse	IDA	J:90603
Cellular Component	GO:0001772	immunological synapse	IDA	J:89810
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:123637
Cellular Component	GO:0005886	plasma membrane	IDA	J:123637
Cellular Component	GO:0005886	plasma membrane	ISO	J:73065
Cellular Component	GO:0042101	T cell receptor complex	ISO	J:73065
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0097190	apoptotic signaling pathway	IDA	J:33466
Biological Process	GO:0019722	calcium-mediated signaling	IDA	J:27768
Biological Process	GO:0019722	calcium-mediated signaling	IDA	J:125137
Biological Process	GO:0019722	calcium-mediated signaling	IDA	J:27768
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	IDA	J:17350
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	IDA	J:75401
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	IDA	J:89097
Biological Process	GO:0007166	cell surface receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:125137
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:27768
Biological Process	GO:0021549	cerebellum development	IMP	J:123637
Biological Process	GO:0016358	dendrite development	IMP	J:123637
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0032633	interleukin-4 production	IDA	J:75401
Biological Process	GO:0046649	lymphocyte activation	IMP	J:98403
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IDA	J:64180
Biological Process	GO:0045060	negative thymic T cell selection	IDA	J:27768
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:98326
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	IDA	J:125137
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	IDA	J:27768
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA	J:17350
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA	J:75401
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA	J:89097
Biological Process	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin	IGI	J:265617
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	IGI	J:265617
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IDA	J:142709
Biological Process	GO:0032753	positive regulation of interleukin-4 production	IDA	J:75401
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:98326
Biological Process	GO:0050870	positive regulation of T cell activation	IDA	J:142709
Biological Process	GO:0002669	positive regulation of T cell anergy	IDA	J:89097
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:164563
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:155856
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:92334
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:98326
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:142709
Biological Process	GO:0042102	positive regulation of T cell proliferation	IDA	J:53400
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:75401
Biological Process	GO:0045059	positive thymic T cell selection	IBA	J:265628
Biological Process	GO:0007584	response to nutrient	ISO	J:155856
Biological Process	GO:0007224	smoothened signaling pathway	IDA	J:64180
Biological Process	GO:0007224	smoothened signaling pathway	IDA	J:64180
Biological Process	GO:0042110	T cell activation	IDA	J:142709
Biological Process	GO:0002870	T cell anergy	IDA	J:89097
Biological Process	GO:0031295	T cell costimulation	IGI	J:205441
Biological Process	GO:0042098	T cell proliferation	IDA	J:142709
Biological Process	GO:0042098	T cell proliferation	IDA	J:53400
Biological Process	GO:0042098	T cell proliferation	IDA	J:98326
Biological Process	GO:0042098	T cell proliferation	IDA	J:92334
Biological Process	GO:0050852	T cell receptor signaling pathway	IDA	J:98326
Biological Process	GO:0032609	type II interferon production	IDA	J:75401