GO Annotations Graph

• Symbol: Cd40
• Name: CD40 antigen
• ID: MGI:88336

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003823	antigen binding	ISO	J:155856
Molecular Function	GO:0003823	antigen binding	IBA	J:265628
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:161997
Molecular Function	GO:0005515	protein binding	IPI	J:171920
Molecular Function	GO:0005515	protein binding	IPI	J:194553
Molecular Function	GO:0005515	protein binding	IPI	J:245282
Molecular Function	GO:0005515	protein binding	IPI	J:36721
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0038023	signaling receptor activity	IEA	J:72247
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0035631	CD40 receptor complex	IDA	J:161997
Cellular Component	GO:0035631	CD40 receptor complex	IBA	J:265628
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:166799
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:91939
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:64603
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:30239
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:86264
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:143981
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:140121
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IDA	J:115064
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:161997
Cellular Component	GO:0043196	varicosity	ISO	J:155856
Biological Process	GO:0042113	B cell activation	ISO	J:155856
Biological Process	GO:0042113	B cell activation	IBA	J:265628
Biological Process	GO:0042113	B cell activation	IDA	J:113321
Biological Process	GO:0042113	B cell activation	IDA	J:87555
Biological Process	GO:0019724	B cell mediated immunity	IGI	J:138560
Biological Process	GO:0019724	B cell mediated immunity	IGI	J:138560
Biological Process	GO:0042100	B cell proliferation	IDA	J:75401
Biological Process	GO:0042100	B cell proliferation	IDA	J:33466
Biological Process	GO:0042100	B cell proliferation	IDA	J:64603
Biological Process	GO:0042100	B cell proliferation	IDA	J:106733
Biological Process	GO:0042100	B cell proliferation	IGI	J:103908
Biological Process	GO:0042100	B cell proliferation	IGI	J:103908
Biological Process	GO:0042100	B cell proliferation	IDA	J:125136
Biological Process	GO:0023035	CD40 signaling pathway	ISO	J:164563
Biological Process	GO:0023035	CD40 signaling pathway	IBA	J:265628
Biological Process	GO:0023035	CD40 signaling pathway	IGI	J:138560
Biological Process	GO:0071347	cellular response to interleukin-1	IBA	J:265628
Biological Process	GO:0071356	cellular response to tumor necrosis factor	IBA	J:265628
Biological Process	GO:0042832	defense response to protozoan	IBA	J:265628
Biological Process	GO:0042832	defense response to protozoan	IDA	J:143745
Biological Process	GO:0051607	defense response to virus	IBA	J:265628
Biological Process	GO:0051607	defense response to virus	IDA	J:143981
Biological Process	GO:0002768	immune response-regulating cell surface receptor signaling pathway	IBA	J:265628
Biological Process	GO:0002768	immune response-regulating cell surface receptor signaling pathway	IDA	J:91939
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0002377	immunoglobulin production	IGI	J:138560
Biological Process	GO:0002377	immunoglobulin production	IGI	J:138560
Biological Process	GO:0006954	inflammatory response	ISO	J:155856
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0032615	interleukin-12 production	IDA	J:91939
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IMP	J:180537
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	IBA	J:265628
Biological Process	GO:0030890	positive regulation of B cell proliferation	IBA	J:265628
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:106733
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:33466
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:125136
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:75401
Biological Process	GO:0030890	positive regulation of B cell proliferation	IGI	J:103908
Biological Process	GO:0030890	positive regulation of B cell proliferation	IDA	J:64603
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	IBA	J:265628
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	IBA	J:265628
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IBA	J:265628
Biological Process	GO:0032735	positive regulation of interleukin-12 production	IDA	J:91939
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IBA	J:265628
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IDA	J:84929
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0090037	positive regulation of protein kinase C signaling	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IBA	J:265628
Biological Process	GO:0043491	protein kinase B signaling	IDA	J:113321
Biological Process	GO:0050776	regulation of immune response	IDA	J:84929
Biological Process	GO:0002637	regulation of immunoglobulin production	IDA	J:86592
Biological Process	GO:0034341	response to type II interferon	IBA	J:265628
Biological Process	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	IBA	J:265628