GO Annotations Graph

• Symbol: Cdk1
• Name: cyclin dependent kinase 1
• ID: MGI:88351

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0010698	acetyltransferase activator activity	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0001671	ATPase activator activity	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:140237
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	ISO	J:155856
Molecular Function	GO:0030332	cyclin binding	ISO	J:24521
Molecular Function	GO:0097472	cyclin-dependent protein kinase activity	ISO	J:164563
Molecular Function	GO:0097472	cyclin-dependent protein kinase activity	IDA	J:239026
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IDA	J:183245
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0008047	enzyme activator activity	ISO	J:164563
Molecular Function	GO:0035173	histone kinase activity	ISO	J:164563
Molecular Function	GO:0035173	histone kinase activity	ISO	J:155856
Molecular Function	GO:0030544	Hsp70 protein binding	IPI	J:77458
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IDA	J:78410
Molecular Function	GO:0016301	kinase activity	IDA	J:86382
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:183245
Molecular Function	GO:0005515	protein binding	IPI	J:155178
Molecular Function	GO:0005515	protein binding	IPI	J:124678
Molecular Function	GO:0005515	protein binding	IPI	J:191743
Molecular Function	GO:0005515	protein binding	IPI	J:73639
Molecular Function	GO:0005515	protein binding	IPI	J:78410
Molecular Function	GO:0005515	protein binding	IPI	J:78410
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:199766
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:272927
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0097125	cyclin B1-CDK1 complex	ISO	J:164563
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	IDA	J:240380
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0072686	mitotic spindle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8979019
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:101015
Cellular Component	GO:0005876	spindle microtubule	ISO	J:164563
Biological Process	GO:0031100	animal organ regeneration	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0030261	chromosome condensation	ISO	J:155856
Biological Process	GO:0048144	fibroblast proliferation	IDA	J:140237
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0090166	Golgi disassembly	ISO	J:155856
Biological Process	GO:1902850	microtubule cytoskeleton organization involved in mitosis	ISO	J:164563
Biological Process	GO:0044772	mitotic cell cycle phase transition	IMP	J:140237
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	IBA	J:265628
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	IDA	J:86382
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	ISO	J:155856
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:155856
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:1905448	positive regulation of mitochondrial ATP synthesis coupled electron transport	ISO	J:164563
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	ISO	J:155856
Biological Process	GO:0062033	positive regulation of mitotic sister chromatid segregation	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:155856
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0034501	protein localization to kinetochore	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:146172
Biological Process	GO:0006468	protein phosphorylation	IDA	J:78410
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:155856
Biological Process	GO:0042752	regulation of circadian rhythm	ISO	J:164563
Biological Process	GO:0045471	response to ethanol	ISO	J:155856
Biological Process	GO:0010243	response to organonitrogen compound	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000