Cdk4 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Cdk4
cyclin dependent kinase 4
MGI:88357

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	ISO	J:155856
Molecular Function	GO:0030332	cyclin binding	IBA	J:265628
Molecular Function	GO:0030332	cyclin binding	IPI	J:190888
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IDA	J:85481
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IDA	J:85809
Molecular Function	GO:0016301	kinase activity	IDA	J:78410
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:105045
Molecular Function	GO:0005515	protein binding	IPI	J:201309
Molecular Function	GO:0005515	protein binding	IPI	J:201309
Molecular Function	GO:0005515	protein binding	IPI	J:105043
Molecular Function	GO:0005515	protein binding	IPI	J:165553
Molecular Function	GO:0005515	protein binding	IPI	J:118785
Molecular Function	GO:0005515	protein binding	IPI	J:125912
Molecular Function	GO:0005515	protein binding	IPI	J:105045
Molecular Function	GO:0005515	protein binding	IPI	J:119990
Molecular Function	GO:0005515	protein binding	IPI	J:127604
Molecular Function	GO:0005515	protein binding	IPI	J:111799
Molecular Function	GO:0005515	protein binding	IPI	J:219103
Molecular Function	GO:0005515	protein binding	IPI	J:162977
Molecular Function	GO:0005515	protein binding	IPI	J:182377
Molecular Function	GO:0005515	protein binding	IPI	J:158603
Molecular Function	GO:0005515	protein binding	IPI	J:147145
Molecular Function	GO:0005515	protein binding	IPI	J:77997
Molecular Function	GO:0005515	protein binding	IPI	J:82317
Molecular Function	GO:0005515	protein binding	IPI	J:230033
Molecular Function	GO:0005515	protein binding	IPI	J:171849
Molecular Function	GO:0005515	protein binding	IPI	J:19218
Molecular Function	GO:0005515	protein binding	IPI	J:78410
Molecular Function	GO:0005515	protein binding	IPI	J:85809
Molecular Function	GO:0004672	protein kinase activity	IDA	J:82317
Molecular Function	GO:0004672	protein kinase activity	IDA	J:77997
Molecular Function	GO:0004672	protein kinase activity	IDA	J:174697
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IMP	J:230033
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:182969
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0097128	cyclin D1-CDK4 complex	ISO	J:164563
Cellular Component	GO:0097128	cyclin D1-CDK4 complex	IPI	J:127604
Cellular Component	GO:0097129	cyclin D2-CDK4 complex	ISO	J:164563
Cellular Component	GO:0097129	cyclin D2-CDK4 complex	IDA	J:30542
Cellular Component	GO:0097129	cyclin D2-CDK4 complex	IDA	J:24521
Cellular Component	GO:0097130	cyclin D3-CDK4 complex	ISO	J:164563
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	ISO	J:164563
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IBA	J:265628
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:230033
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031965	nuclear membrane	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-182564
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912421
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912431
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912462
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912487
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:230033
Cellular Component	GO:0005634	nucleus	IDA	J:95925
Cellular Component	GO:0005634	nucleus	IDA	J:85130
Cellular Component	GO:0005634	nucleus	IDA	J:37447
Cellular Component	GO:0005634	nucleus	IDA	J:95925
Cellular Component	GO:0005634	nucleus	ISO	J:101015
Cellular Component	GO:0005634	nucleus	IDA	J:53930
Cellular Component	GO:0005634	nucleus	IDA	J:95925
Cellular Component	GO:0005634	nucleus	IDA	J:182969
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IDA	J:230033
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:53930
Biological Process	GO:0060612	adipose tissue development	IMP	J:230033
Biological Process	GO:0060612	adipose tissue development	IMP	J:230033
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0032869	cellular response to insulin stimulus	IMP	J:230033
Biological Process	GO:0071353	cellular response to interleukin-4	IDA	J:30542
Biological Process	GO:1904637	cellular response to ionomycin	IDA	J:30542
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IDA	J:30542
Biological Process	GO:1904628	cellular response to phorbol 13-acetate 12-myristate	IDA	J:30542
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	NAS	J:320000
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045793	positive regulation of cell size	ISO	J:155856
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:82317
Biological Process	GO:0006468	protein phosphorylation	IDA	J:78410
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:82317
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0010468	regulation of gene expression	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IBA	J:265628
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	IMP	J:230033
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	IMP	J:230033
Biological Process	GO:0046890	regulation of lipid biosynthetic process	IMP	J:230033
Biological Process	GO:0046890	regulation of lipid biosynthetic process	IMP	J:230033
Biological Process	GO:0050994	regulation of lipid catabolic process	IMP	J:230033
Biological Process	GO:0050994	regulation of lipid catabolic process	IMP	J:230033
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:230033
Biological Process	GO:0040014	regulation of multicellular organism growth	IMP	J:230033
Biological Process	GO:0061469	regulation of type B pancreatic cell proliferation	IMP	J:85130
Biological Process	GO:0061469	regulation of type B pancreatic cell proliferation	IMP	J:85130
Biological Process	GO:0010288	response to lead ion	ISO	J:155856
Biological Process	GO:0010033	response to organic substance	ISO	J:155856
Biological Process	GO:0010033	response to organic substance	IBA	J:265628
Biological Process	GO:0033574	response to testosterone	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IDA	J:77997

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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