GO Annotations Graph

• Symbol: Cntf
• Name: ciliary neurotrophic factor
• ID: MGI:88439

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005127	ciliary neurotrophic factor receptor binding	ISO	J:155856
Molecular Function	GO:0005127	ciliary neurotrophic factor receptor binding	IBA	J:265628
Molecular Function	GO:0005125	cytokine activity	ISO	J:155856
Molecular Function	GO:0005125	cytokine activity	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	ISO	J:164563
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:0005138	interleukin-6 receptor binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:90895
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0032838	plasma membrane bounded cell projection cytoplasm	ISO	J:155856
Biological Process	GO:0048143	astrocyte activation	ISO	J:155856
Biological Process	GO:0048143	astrocyte activation	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0060081	membrane hyperpolarization	ISO	J:155856
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0048644	muscle organ morphogenesis	IGI	J:97380
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IBA	J:265628
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0046533	negative regulation of photoreceptor cell differentiation	IDA	J:90895
Biological Process	GO:0007399	nervous system development	ISO	J:155856
Biological Process	GO:0048666	neuron development	IGI	J:97380
Biological Process	GO:0048691	positive regulation of axon extension involved in regeneration	ISO	J:155856
Biological Process	GO:0048680	positive regulation of axon regeneration	ISO	J:155856
Biological Process	GO:0048680	positive regulation of axon regeneration	IBA	J:265628
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:89246
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:89246
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:206059
Biological Process	GO:0046887	positive regulation of hormone secretion	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IBA	J:265628
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IDA	J:90895
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	ISO	J:155856
Biological Process	GO:0060075	regulation of resting membrane potential	ISO	J:155856
Biological Process	GO:0046668	regulation of retinal cell programmed cell death	IDA	J:73377
Biological Process	GO:0060221	retinal rod cell differentiation	IDA	J:90895
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IDA	J:90895