GO Annotations Graph

• Symbol: Col1a1
• Name: collagen, type I, alpha 1
• ID: MGI:88467

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005201	extracellular matrix structural constituent	IBA	J:265628
Molecular Function	GO:0005201	extracellular matrix structural constituent	IDA	J:113133
Molecular Function	GO:0030020	extracellular matrix structural constituent conferring tensile strength	RCA	J:265607
Molecular Function	GO:0030020	extracellular matrix structural constituent conferring tensile strength	RCA	J:265604
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	IPI	J:41877
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0048407	platelet-derived growth factor binding	ISO	J:73065
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:117639
Molecular Function	GO:0005515	protein binding	IPI	J:117639
Molecular Function	GO:0005515	protein binding	IPI	J:27457
Molecular Function	GO:0005515	protein binding	IPI	J:41877
Molecular Function	GO:0005515	protein binding	IPI	J:27457
Cellular Component	GO:0005581	collagen trimer	IDA	J:34409
Cellular Component	GO:0005581	collagen trimer	IDA	J:59168
Cellular Component	GO:0005581	collagen trimer	IDA	J:22301
Cellular Component	GO:0005581	collagen trimer	IDA	J:113133
Cellular Component	GO:0005581	collagen trimer	IMP	J:92016
Cellular Component	GO:0005581	collagen trimer	IDA	J:128284
Cellular Component	GO:0005584	collagen type I trimer	ISO	J:164563
Cellular Component	GO:0005584	collagen type I trimer	IBA	J:265628
Cellular Component	GO:0005584	collagen type I trimer	IDA	J:19003
Cellular Component	GO:0005584	collagen type I trimer	IMP	J:26504
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:213088
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IDA	J:311083
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:19003
Cellular Component	GO:0005737	cytoplasm	IDA	J:268890
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0031012	extracellular matrix	IBA	J:265628
Cellular Component	GO:0031012	extracellular matrix	IDA	J:30059
Cellular Component	GO:0031012	extracellular matrix	IDA	J:36211
Cellular Component	GO:0031012	extracellular matrix	IDA	J:28286
Cellular Component	GO:0031012	extracellular matrix	IDA	J:28978
Cellular Component	GO:0031012	extracellular matrix	IDA	J:116643
Cellular Component	GO:0031012	extracellular matrix	IDA	J:116643
Cellular Component	GO:0031012	extracellular matrix	IDA	J:116643
Cellular Component	GO:0031012	extracellular matrix	IDA	J:32939
Cellular Component	GO:0031012	extracellular matrix	IDA	J:27457
Cellular Component	GO:0031012	extracellular matrix	IDA	J:63311
Cellular Component	GO:0031012	extracellular matrix	IDA	J:30059
Cellular Component	GO:0031012	extracellular matrix	IDA	J:30059
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-8985650
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:311083
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Biological Process	GO:0001568	blood vessel development	ISO	J:164563
Biological Process	GO:0001568	blood vessel development	IBA	J:265628
Biological Process	GO:0001568	blood vessel development	IMP	J:92016
Biological Process	GO:0060346	bone trabecula formation	IGI	J:121546
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	IMP	J:129569
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	IMP	J:129569
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	IMP	J:129569
Biological Process	GO:0071230	cellular response to amino acid stimulus	IDA	J:164409
Biological Process	GO:0071260	cellular response to mechanical stimulus	IEP	J:177225
Biological Process	GO:0032964	collagen biosynthetic process	ISO	J:164563
Biological Process	GO:0030199	collagen fibril organization	ISO	J:164563
Biological Process	GO:0030199	collagen fibril organization	NAS	J:320124
Biological Process	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	ISO	J:64375
Biological Process	GO:0048706	embryonic skeletal system development	ISO	J:164563
Biological Process	GO:0001958	endochondral ossification	IMP	J:16630
Biological Process	GO:0030198	extracellular matrix organization	IBA	J:265628
Biological Process	GO:0060325	face morphogenesis	IGI	J:121546
Biological Process	GO:0001957	intramembranous ossification	IGI	J:121546
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	IDA	J:117639
Biological Process	GO:0001503	ossification	IBA	J:265628
Biological Process	GO:0001649	osteoblast differentiation	IEP	J:143682
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0034504	protein localization to nucleus	ISO	J:164563
Biological Process	GO:0015031	protein transport	IMP	J:36211
Biological Process	GO:0009612	response to mechanical stimulus	IBA	J:265628
Biological Process	GO:0007605	sensory perception of sound	ISO	J:164563
Biological Process	GO:0001501	skeletal system development	IBA	J:265628
Biological Process	GO:0001501	skeletal system development	ISO	J:73065
Biological Process	GO:0001501	skeletal system development	IMP	J:17578
Biological Process	GO:0048705	skeletal system morphogenesis	IGI	J:121546
Biological Process	GO:0043588	skin development	IBA	J:265628
Biological Process	GO:0043588	skin development	IMP	J:129569
Biological Process	GO:0043589	skin morphogenesis	ISO	J:164563
Biological Process	GO:0034505	tooth mineralization	ISO	J:164563
Biological Process	GO:0007601	visual perception	ISO	J:164563
Biological Process	GO:0042060	wound healing	ISO	J:155856