GO Annotations Graph

• Symbol: Col1a2
• Name: collagen, type I, alpha 2
• ID: MGI:88468

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005201	extracellular matrix structural constituent	IBA	J:265628
Molecular Function	GO:0030020	extracellular matrix structural constituent conferring tensile strength	RCA	J:265604
Molecular Function	GO:0030020	extracellular matrix structural constituent conferring tensile strength	RCA	J:265607
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0048407	platelet-derived growth factor binding	ISO	J:73065
Molecular Function	GO:0002020	protease binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:27457
Molecular Function	GO:0005515	protein binding	IPI	J:41877
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	IPI	J:86396
Molecular Function	GO:0046332	SMAD binding	IPI	J:86396
Molecular Function	GO:0046332	SMAD binding	IPI	J:86396
Cellular Component	GO:0005581	collagen trimer	IDA	J:34409
Cellular Component	GO:0005581	collagen trimer	IDA	J:128284
Cellular Component	GO:0005581	collagen trimer	IDA	J:59168
Cellular Component	GO:0005584	collagen type I trimer	ISO	J:164563
Cellular Component	GO:0005584	collagen type I trimer	IBA	J:265628
Cellular Component	GO:0005584	collagen type I trimer	IDA	J:20667
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:213088
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IDA	J:311083
Cellular Component	GO:0031012	extracellular matrix	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005615	extracellular space	IDA	J:157951
Biological Process	GO:0001568	blood vessel development	ISO	J:164563
Biological Process	GO:0030282	bone mineralization	IMP	J:193344
Biological Process	GO:0071230	cellular response to amino acid stimulus	IDA	J:164409
Biological Process	GO:0030199	collagen fibril organization	ISO	J:164563
Biological Process	GO:0030199	collagen fibril organization	NAS	J:320124
Biological Process	GO:0032963	collagen metabolic process	IMP	J:193344
Biological Process	GO:0085029	extracellular matrix assembly	IMP	J:193344
Biological Process	GO:0030198	extracellular matrix organization	IBA	J:265628
Biological Process	GO:0070208	protein heterotrimerization	IDA	J:41877
Biological Process	GO:0008217	regulation of blood pressure	ISO	J:164563
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0001501	skeletal system development	ISO	J:164563
Biological Process	GO:0043589	skin morphogenesis	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563