GO Annotations Graph

• Symbol: Comt
• Name: catechol-O-methyltransferase
• ID: MGI:88470

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016206	catechol O-methyltransferase activity	ISO	J:155856
Molecular Function	GO:0016206	catechol O-methyltransferase activity	ISO	J:164563
Molecular Function	GO:0016206	catechol O-methyltransferase activity	IBA	J:265628
Molecular Function	GO:0016206	catechol O-methyltransferase activity	IDA	J:163569
Molecular Function	GO:0102084	L-dopa O-methyltransferase activity	IEA	J:72245
Molecular Function	GO:0000287	magnesium ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008168	methyltransferase activity	IEA	J:60000
Molecular Function	GO:0008171	O-methyltransferase activity	IEA	J:72247
Molecular Function	GO:0102938	orcinol O-methyltransferase activity	IEA	J:72245
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Biological Process	GO:0042424	catecholamine catabolic process	ISO	J:164563
Biological Process	GO:0042424	catecholamine catabolic process	IBA	J:265628
Biological Process	GO:0006584	catecholamine metabolic process	IEA	J:72247
Biological Process	GO:0006584	catecholamine metabolic process	IEA	J:60000
Biological Process	GO:0016036	cellular response to phosphate starvation	IDA	J:200928
Biological Process	GO:0032502	developmental process	IBA	J:265628
Biological Process	GO:0042420	dopamine catabolic process	IDA	J:79010
Biological Process	GO:0042417	dopamine metabolic process	IBA	J:265628
Biological Process	GO:0042417	dopamine metabolic process	IDA	J:200928
Biological Process	GO:0008210	estrogen metabolic process	ISO	J:155856
Biological Process	GO:0007565	female pregnancy	ISO	J:155856
Biological Process	GO:0007612	learning	ISO	J:155856
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0032259	methylation	ISO	J:164563
Biological Process	GO:0048609	multicellular organismal reproductive process	ISO	J:155856
Biological Process	GO:0045963	negative regulation of dopamine metabolic process	ISO	J:155856
Biological Process	GO:0035814	negative regulation of renal sodium excretion	ISO	J:155856
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0042135	neurotransmitter catabolic process	IDA	J:164700
Biological Process	GO:0042135	neurotransmitter catabolic process	IMP	J:164700
Biological Process	GO:0050668	positive regulation of homocysteine metabolic process	ISO	J:155856
Biological Process	GO:0051930	regulation of sensory perception of pain	ISO	J:155856
Biological Process	GO:0048265	response to pain	ISO	J:155856
Biological Process	GO:0007614	short-term memory	ISO	J:155856