GO Annotations Graph

• Symbol: Cr2
• Name: complement receptor 2
• ID: MGI:88489

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001848	complement binding	ISO	J:164563
Molecular Function	GO:0004875	complement receptor activity	IMP	J:73128
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0034987	immunoglobulin receptor binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:73128
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:73128
Molecular Function	GO:0038023	signaling receptor activity	IDA	J:73128
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:99189
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:110739
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:87927
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:110739
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:19437
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:148242
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0030183	B cell differentiation	ISO	J:164563
Biological Process	GO:0042100	B cell proliferation	ISO	J:164563
Biological Process	GO:0060348	bone development	IGI	J:156611
Biological Process	GO:0051216	cartilage development	IGI	J:156611
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IGI	J:156611
Biological Process	GO:0006957	complement activation, alternative pathway	ISO	J:164563
Biological Process	GO:0006957	complement activation, alternative pathway	IGI	J:156611
Biological Process	GO:0006958	complement activation, classical pathway	IEA	J:60000
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0016064	immunoglobulin mediated immune response	IGI	J:156611
Biological Process	GO:0006954	inflammatory response	IGI	J:156611
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0045959	negative regulation of complement activation, classical pathway	IBA	J:265628
Biological Process	GO:0002456	T cell mediated immunity	IBA	J:265628