GO Annotations Graph

• Symbol: Creb1
• Name: cAMP responsive element binding protein 1
• ID: MGI:88494

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:1990763	arrestin family protein binding	ISO	J:155856
Molecular Function	GO:0035497	cAMP response element binding	ISO	J:164563
Molecular Function	GO:0035497	cAMP response element binding	IDA	J:287038
Molecular Function	GO:0035497	cAMP response element binding	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	IDA	J:87555
Molecular Function	GO:0003677	DNA binding	IDA	J:74131
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:165661
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:155856
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:79339
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:35340
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:155856
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0035035	histone acetyltransferase binding	ISO	J:155856
Molecular Function	GO:0030544	Hsp70 protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:206837
Molecular Function	GO:0005515	protein binding	IPI	J:180535
Molecular Function	GO:0005515	protein binding	IPI	J:136439
Molecular Function	GO:0005515	protein binding	IPI	J:122746
Molecular Function	GO:0005515	protein binding	IPI	J:166840
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:245403
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:90056
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:155856
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:155856
Cellular Component	GO:1990589	ATF4-CREB1 transcription factor complex	ISO	J:164563
Cellular Component	GO:1990589	ATF4-CREB1 transcription factor complex	IDA	J:217287
Cellular Component	GO:1990589	ATF4-CREB1 transcription factor complex	IBA	J:265628
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0000785	chromatin	IDA	J:287038
Cellular Component	GO:0000785	chromatin	IDA	J:166020
Cellular Component	GO:0000785	chromatin	IMP	J:165661
Cellular Component	GO:0000791	euchromatin	ISO	J:164563
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2976706
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9021848
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9021887
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9021925
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9022187
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9617214
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9620391
Cellular Component	GO:0005634	nucleus	IDA	J:180535
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	NAS	J:217287
Cellular Component	GO:0005634	nucleus	IDA	J:102188
Cellular Component	GO:0005634	nucleus	IDA	J:171712
Cellular Component	GO:0005634	nucleus	ISO	J:35340
Cellular Component	GO:0005634	nucleus	ISO	J:144729
Cellular Component	GO:0005634	nucleus	IDA	J:85958
Cellular Component	GO:0005634	nucleus	IDA	J:99784
Cellular Component	GO:0005634	nucleus	IDA	J:99289
Cellular Component	GO:0005634	nucleus	IDA	J:29402
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	IPI	J:217287
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:155856
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:74131
Biological Process	GO:0007409	axonogenesis	IMP	J:76363
Biological Process	GO:0019933	cAMP-mediated signaling	ISO	J:250701
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:1904322	cellular response to forskolin	ISO	J:250701
Biological Process	GO:0071363	cellular response to growth factor stimulus	IDA	J:166020
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	IDA	J:166840
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0071300	cellular response to retinoic acid	IMP	J:165661
Biological Process	GO:0071294	cellular response to zinc ion	IDA	J:197394
Biological Process	GO:0034670	chemotaxis to arachidonic acid	ISO	J:155856
Biological Process	GO:0007623	circadian rhythm	IDA	J:209480
Biological Process	GO:0046879	hormone secretion	IMP	J:104066
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	ISO	J:250701
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	ISO	J:250701
Biological Process	GO:0007595	lactation	IMP	J:104066
Biological Process	GO:0060428	lung epithelium development	IMP	J:171712
Biological Process	GO:0060428	lung epithelium development	IMP	J:171712
Biological Process	GO:0060428	lung epithelium development	IMP	J:171712
Biological Process	GO:0060428	lung epithelium development	IMP	J:171712
Biological Process	GO:0060428	lung epithelium development	IMP	J:171712
Biological Process	GO:0060430	lung saccule development	IMP	J:171712
Biological Process	GO:0060430	lung saccule development	IMP	J:171712
Biological Process	GO:0060430	lung saccule development	IMP	J:171712
Biological Process	GO:0060430	lung saccule development	IMP	J:171712
Biological Process	GO:0060430	lung saccule development	IMP	J:171712
Biological Process	GO:0030879	mammary gland development	IMP	J:104066
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0007613	memory	IMP	J:193188
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	ISO	J:250701
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	ISO	J:164563
Biological Process	GO:0030316	osteoclast differentiation	IDA	J:198051
Biological Process	GO:0021983	pituitary gland development	IMP	J:104066
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0055025	positive regulation of cardiac muscle tissue development	IMP	J:210551
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IGI	J:180535
Biological Process	GO:0045600	positive regulation of fat cell differentiation	IGI	J:180535
Biological Process	GO:0046887	positive regulation of hormone secretion	IMP	J:104066
Biological Process	GO:0046889	positive regulation of lipid biosynthetic process	IGI	J:180535
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IMP	J:104066
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	IDA	J:198051
Biological Process	GO:0045899	positive regulation of RNA polymerase II transcription preinitiation complex assembly	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:165661
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:209480
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:35340
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:135327
Biological Process	GO:0032916	positive regulation of transforming growth factor beta3 production	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:35340
Biological Process	GO:0050821	protein stabilization	IMP	J:180535
Biological Process	GO:0042981	regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0008361	regulation of cell size	IGI	J:76484
Biological Process	GO:0042752	regulation of circadian rhythm	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:79339
Biological Process	GO:0048145	regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0060251	regulation of glial cell proliferation	ISO	J:155856
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:217287
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:1903494	response to dehydroepiandrosterone	ISO	J:155856
Biological Process	GO:0036017	response to erythropoietin	ISO	J:155856
Biological Process	GO:0033762	response to glucagon	IMP	J:209480
Biological Process	GO:1990910	response to hypobaric hypoxia	ISO	J:155856
Biological Process	GO:0010035	response to inorganic substance	ISO	J:250701
Biological Process	GO:0010035	response to inorganic substance	IMP	J:250701
Biological Process	GO:0010033	response to organic substance	ISO	J:35340
Biological Process	GO:0014074	response to purine-containing compound	ISO	J:250701
Biological Process	GO:0009410	response to xenobiotic stimulus	IDA	J:40102
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0033363	secretory granule organization	IMP	J:171712
Biological Process	GO:0033363	secretory granule organization	IMP	J:171712
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0060509	type I pneumocyte differentiation	IMP	J:171712
Biological Process	GO:0060509	type I pneumocyte differentiation	IMP	J:171712
Biological Process	GO:0008542	visual learning	ISO	J:155856