GO Annotations Graph

• Symbol: Crhr1
• Name: corticotropin releasing hormone receptor 1
• ID: MGI:88498

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015056	corticotrophin-releasing factor receptor activity	IMP	J:48280
Molecular Function	GO:0015056	corticotrophin-releasing factor receptor activity	ISO	J:164563
Molecular Function	GO:0015056	corticotrophin-releasing factor receptor activity	IBA	J:265628
Molecular Function	GO:0015056	corticotrophin-releasing factor receptor activity	IMP	J:76358
Molecular Function	GO:0051424	corticotropin-releasing hormone binding	ISO	J:155856
Molecular Function	GO:0051424	corticotropin-releasing hormone binding	IBA	J:265628
Molecular Function	GO:0043404	corticotropin-releasing hormone receptor activity	ISO	J:155856
Molecular Function	GO:0043404	corticotropin-releasing hormone receptor activity	IBA	J:265628
Molecular Function	GO:0008528	G protein-coupled peptide receptor activity	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	ISO	J:155856
Molecular Function	GO:0001965	G-protein alpha-subunit binding	ISO	J:155856
Molecular Function	GO:0042277	peptide binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:263407
Molecular Function	GO:0005515	protein binding	IPI	J:263407
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IEA	J:72247
Cellular Component	GO:0045177	apical part of cell	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005771	multivesicular body	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005802	trans-Golgi network	ISO	J:155856
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:48280
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0030325	adrenal gland development	IMP	J:48280
Biological Process	GO:0048148	behavioral response to cocaine	ISO	J:155856
Biological Process	GO:0048149	behavioral response to ethanol	IMP	J:76358
Biological Process	GO:0048266	behavioral response to pain	ISO	J:155856
Biological Process	GO:0007166	cell surface receptor signaling pathway	IEA	J:72247
Biological Process	GO:0071376	cellular response to corticotropin-releasing hormone stimulus	IMP	J:48280
Biological Process	GO:0051458	corticotropin secretion	IMP	J:48280
Biological Process	GO:0030855	epithelial cell differentiation	ISO	J:155856
Biological Process	GO:0042596	fear response	IMP	J:48280
Biological Process	GO:0007631	feeding behavior	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0051867	general adaptation syndrome, behavioral process	IMP	J:76358
Biological Process	GO:0035641	locomotory exploration behavior	ISO	J:155856
Biological Process	GO:0060291	long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0032811	negative regulation of epinephrine secretion	ISO	J:155856
Biological Process	GO:2000252	negative regulation of feeding behavior	ISO	J:155856
Biological Process	GO:1901215	negative regulation of neuron death	ISO	J:155856
Biological Process	GO:0007218	neuropeptide signaling pathway	ISO	J:155856
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0043306	positive regulation of mast cell degranulation	ISO	J:155856
Biological Process	GO:2000852	regulation of corticosterone secretion	IMP	J:48280
Biological Process	GO:0048167	regulation of synaptic plasticity	ISO	J:155856
Biological Process	GO:0051602	response to electrical stimulus	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0008542	visual learning	ISO	J:155856