GO Annotations Graph

• Symbol: Cryab
• Name: crystallin, alpha B
• ID: MGI:88516

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	ISO	J:164563
Molecular Function	GO:0008092	cytoskeletal protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008017	microtubule binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:255328
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:200485
Molecular Function	GO:0005515	protein binding	IPI	J:132296
Molecular Function	GO:0005515	protein binding	IPI	J:132296
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0005212	structural constituent of eye lens	TAS	J:86897
Molecular Function	GO:0005198	structural molecule activity	ISO	J:164563
Molecular Function	GO:0051082	unfolded protein binding	ISO	J:164563
Cellular Component	GO:0032432	actin filament bundle	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0097512	cardiac myofibril	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0043292	contractile fiber	IDA	J:87935
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:132494
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0031674	I band	ISO	J:155856
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0031430	M band	ISO	J:155856
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IDA	J:132494
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:87935
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0045202	synapse	ISO	J:155856
Cellular Component	GO:0097060	synaptic membrane	ISO	J:155856
Cellular Component	GO:0030018	Z disc	IDA	J:87935
Biological Process	GO:0060561	apoptotic process involved in morphogenesis	IGI	J:106028
Biological Process	GO:0043010	camera-type eye development	IGI	J:86897
Biological Process	GO:0071480	cellular response to gamma radiation	ISO	J:195510
Biological Process	GO:0002088	lens development in camera-type eye	IGI	J:106028
Biological Process	GO:0031109	microtubule polymerization or depolymerization	ISO	J:155856
Biological Process	GO:0007517	muscle organ development	IGI	J:72926
Biological Process	GO:1905907	negative regulation of amyloid fibril formation	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:132494
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:155856
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IGI	J:106028
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:125299
Biological Process	GO:0032387	negative regulation of intracellular transport	ISO	J:164563
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	ISO	J:155856
Biological Process	GO:0006457	protein folding	ISO	J:155856
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0043067	regulation of programmed cell death	ISO	J:195510
Biological Process	GO:0042542	response to hydrogen peroxide	IMP	J:121617
Biological Process	GO:0001666	response to hypoxia	IMP	J:132494
Biological Process	GO:0051403	stress-activated MAPK cascade	ISO	J:155856
Biological Process	GO:0007021	tubulin complex assembly	IMP	J:111251