GO Annotations Graph

• Symbol: Ctsd
• Name: cathepsin D
• ID: MGI:88562

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	IBA	J:265628
Molecular Function	GO:0004190	aspartic-type endopeptidase activity	IDA	J:149618
Molecular Function	GO:0070001	aspartic-type peptidase activity	IMP	J:273521
Molecular Function	GO:0004175	endopeptidase activity	ISO	J:155856
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:237352
Molecular Function	GO:0004175	endopeptidase activity	IDA	J:237673
Molecular Function	GO:0016787	hydrolase activity	IDA	J:164482
Molecular Function	GO:0008233	peptidase activity	ISO	J:164563
Molecular Function	GO:0008233	peptidase activity	IDA	J:95873
Molecular Function	GO:0008233	peptidase activity	IDA	J:111314
Molecular Function	GO:0042277	peptide binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:243041
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0031904	endosome lumen	IDA	J:237352
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:164482
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IDA	J:227553
Cellular Component	GO:0005764	lysosome	ISO	J:155856
Cellular Component	GO:0005764	lysosome	IDA	J:85207
Cellular Component	GO:0005764	lysosome	IDA	J:256294
Cellular Component	GO:0005764	lysosome	IDA	J:48608
Cellular Component	GO:0005764	lysosome	ISO	J:135985
Cellular Component	GO:0005764	lysosome	IDA	J:59828
Cellular Component	GO:0005764	lysosome	IDA	J:102821
Cellular Component	GO:0005764	lysosome	IDA	J:83403
Cellular Component	GO:0005764	lysosome	IDA	J:38944
Cellular Component	GO:0005764	lysosome	ISO	J:73065
Cellular Component	GO:0005764	lysosome	IDA	J:93423
Cellular Component	GO:0045121	membrane raft	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0098830	presynaptic endosome	ISO	J:155856
Biological Process	GO:0000045	autophagosome assembly	IMP	J:93423
Biological Process	GO:1901143	insulin catabolic process	IDA	J:237352
Biological Process	GO:0038020	insulin receptor recycling	IDA	J:237352
Biological Process	GO:0042159	lipoprotein catabolic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:0030163	protein catabolic process	ISO	J:155856
Biological Process	GO:0006508	proteolysis	ISO	J:164563
Biological Process	GO:0006508	proteolysis	IBA	J:265628
Biological Process	GO:0006508	proteolysis	IC	J:95873
Biological Process	GO:0070201	regulation of establishment of protein localization	ISO	J:164563