GO Annotations Graph

• Symbol: Cybb
• Name: cytochrome b-245, beta polypeptide
• ID: MGI:88574

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0009055	electron transfer activity	ISO	J:164563
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISO	J:164563
Molecular Function	GO:0020037	heme binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:172364
Molecular Function	GO:0005515	protein binding	IPI	J:209569
Molecular Function	GO:0005515	protein binding	IPI	J:209569
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	ISO	J:164563
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	IBA	J:265628
Molecular Function	GO:0016175	superoxide-generating NAD(P)H oxidase activity	IDA	J:185616
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:193251
Cellular Component	GO:0005737	cytoplasm	IDA	J:103853
Cellular Component	GO:0005737	cytoplasm	IDA	J:103853
Cellular Component	GO:0005737	cytoplasm	IDA	J:97972
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0043020	NADPH oxidase complex	ISO	J:155856
Cellular Component	GO:0043020	NADPH oxidase complex	ISO	J:164563
Cellular Component	GO:0043020	NADPH oxidase complex	IDA	J:209569
Cellular Component	GO:0043020	NADPH oxidase complex	IBA	J:265628
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005635	nuclear envelope	ISO	J:155856
Cellular Component	GO:0097038	perinuclear endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0045335	phagocytic vesicle	IDA	J:193251
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:103853
Cellular Component	GO:0005886	plasma membrane	IDA	J:103853
Cellular Component	GO:0005791	rough endoplasmic reticulum	ISO	J:155856
Biological Process	GO:0006952	defense response	IBA	J:265628
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	IMP	J:91766
Biological Process	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway	ISO	J:155856
Biological Process	GO:0006954	inflammatory response	IMP	J:209569
Biological Process	GO:0045087	innate immune response	IMP	J:241355
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:155856
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0045730	respiratory burst	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0042554	superoxide anion generation	ISO	J:164563
Biological Process	GO:0042554	superoxide anion generation	IBA	J:265628
Biological Process	GO:0006801	superoxide metabolic process	IMP	J:209569
Biological Process	GO:0006801	superoxide metabolic process	ISO	J:164563