GO Annotations Graph

• Symbol: Cyp1b1
• Name: cytochrome P450, family 1, subfamily b, polypeptide 1
• ID: MGI:88590

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070330	aromatase activity	IEA	J:72245
Molecular Function	GO:0101020	estrogen 16-alpha-hydroxylase activity	ISO	J:164563
Molecular Function	GO:0020037	heme binding	ISO	J:164563
Molecular Function	GO:0106256	hydroperoxy icosatetraenoate dehydratase activity	IEA	J:72245
Molecular Function	GO:0005506	iron ion binding	IEA	J:72247
Molecular Function	GO:0016829	lyase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004497	monooxygenase activity	ISO	J:164563
Molecular Function	GO:0004497	monooxygenase activity	IDA	J:210924
Molecular Function	GO:0004497	monooxygenase activity	ISO	J:155856
Molecular Function	GO:0004497	monooxygenase activity	IDA	J:211385
Molecular Function	GO:0004497	monooxygenase activity	IBA	J:265628
Molecular Function	GO:0016491	oxidoreductase activity	ISO	J:155856
Molecular Function	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA	J:72247
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IDA	J:44195
Molecular Function	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	ISO	J:73065
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	IMP	J:203227
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Biological Process	GO:0001525	angiogenesis	IMP	J:144041
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:164563
Biological Process	GO:0019369	arachidonic acid metabolic process	IDA	J:210924
Biological Process	GO:0042537	benzene-containing compound metabolic process	ISO	J:155856
Biological Process	GO:0043534	blood vessel endothelial cell migration	IMP	J:144041
Biological Process	GO:0043534	blood vessel endothelial cell migration	IMP	J:144041
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:197371
Biological Process	GO:0007155	cell adhesion	IMP	J:205425
Biological Process	GO:0006725	cellular aromatic compound metabolic process	ISO	J:155856
Biological Process	GO:0006725	cellular aromatic compound metabolic process	IDA	J:27812
Biological Process	GO:0006725	cellular aromatic compound metabolic process	IMP	J:44195
Biological Process	GO:0006725	cellular aromatic compound metabolic process	IMP	J:43453
Biological Process	GO:0006725	cellular aromatic compound metabolic process	IMP	J:53827
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IMP	J:205425
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:200218
Biological Process	GO:0030199	collagen fibril organization	IMP	J:205425
Biological Process	GO:0006304	DNA modification	ISO	J:155856
Biological Process	GO:0043542	endothelial cell migration	IMP	J:157662
Biological Process	GO:0071603	endothelial cell-cell adhesion	IMP	J:144041
Biological Process	GO:0008210	estrogen metabolic process	ISO	J:155856
Biological Process	GO:0008210	estrogen metabolic process	IDA	J:211385
Biological Process	GO:0008210	estrogen metabolic process	ISO	J:164563
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IMP	J:197371
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IMP	J:205425
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0046466	membrane lipid catabolic process	IMP	J:144041
Biological Process	GO:0046466	membrane lipid catabolic process	IMP	J:205425
Biological Process	GO:0033629	negative regulation of cell adhesion mediated by integrin	IMP	J:197371
Biological Process	GO:0030336	negative regulation of cell migration	IMP	J:197371
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:197371
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	IMP	J:197371
Biological Process	GO:0006809	nitric oxide biosynthetic process	IMP	J:157662
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:157662
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:197371
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	ISO	J:155856
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:155856
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IMP	J:197371
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0045727	positive regulation of translation	ISO	J:155856
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	IMP	J:197371
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	IMP	J:144041
Biological Process	GO:0009636	response to toxic substance	IMP	J:135804
Biological Process	GO:0061298	retina vasculature development in camera-type eye	IMP	J:144041
Biological Process	GO:0061298	retina vasculature development in camera-type eye	IMP	J:144041
Biological Process	GO:0061304	retinal blood vessel morphogenesis	IMP	J:157662
Biological Process	GO:0042574	retinal metabolic process	ISO	J:164563
Biological Process	GO:0042574	retinal metabolic process	IDA	J:210924
Biological Process	GO:0042572	retinol metabolic process	ISO	J:164563
Biological Process	GO:0042572	retinol metabolic process	IDA	J:210924
Biological Process	GO:0008202	steroid metabolic process	ISO	J:164563
Biological Process	GO:0009404	toxin metabolic process	IMP	J:122123
Biological Process	GO:0009404	toxin metabolic process	IMP	J:53827
Biological Process	GO:0002930	trabecular meshwork development	IMP	J:205425
Biological Process	GO:0006805	xenobiotic metabolic process	ISO	J:164563