Sfrp1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Sfrp1
secreted frizzled-related protein 1
MGI:892014

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004197	cysteine-type endopeptidase activity	ISO	J:164563
Molecular Function	GO:0005109	frizzled binding	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:147775
Molecular Function	GO:0017147	Wnt-protein binding	ISO	J:164563
Molecular Function	GO:0017147	Wnt-protein binding	IBA	J:265628
Molecular Function	GO:0017147	Wnt-protein binding	ISO	J:121773
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:130925
Biological Process	GO:0030036	actin cytoskeleton organization	ISO	J:130925
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:106551
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:157031
Biological Process	GO:0060346	bone trabecula formation	IMP	J:89547
Biological Process	GO:0060070	canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0060070	canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0060070	canonical Wnt signaling pathway	IGI	J:157031
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0071391	cellular response to estrogen stimulus	IDA	J:140742
Biological Process	GO:0071391	cellular response to estrogen stimulus	ISO	J:164563
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:164563
Biological Process	GO:0071504	cellular response to heparin	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0071481	cellular response to X-ray	IDA	J:164747
Biological Process	GO:0090246	convergent extension involved in somitogenesis	IGI	J:135313
Biological Process	GO:0090246	convergent extension involved in somitogenesis	IGI	J:135313
Biological Process	GO:0046546	development of primary male sexual characteristics	IGI	J:147206
Biological Process	GO:0048546	digestive tract morphogenesis	IGI	J:147041
Biological Process	GO:0048546	digestive tract morphogenesis	IGI	J:147041
Biological Process	GO:0048546	digestive tract morphogenesis	IGI	J:147041
Biological Process	GO:0071542	dopaminergic neuron differentiation	IDA	J:227463
Biological Process	GO:0009950	dorsal/ventral axis specification	ISO	J:164563
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:89547
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:89547
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:89547
Biological Process	GO:0008585	female gonad development	IGI	J:147206
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	ISO	J:164563
Biological Process	GO:0060218	hematopoietic stem cell differentiation	ISO	J:164563
Biological Process	GO:0030097	hemopoiesis	IMP	J:152080
Biological Process	GO:0008584	male gonad development	IGI	J:147206
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0045578	negative regulation of B cell differentiation	IMP	J:140742
Biological Process	GO:0045578	negative regulation of B cell differentiation	ISO	J:164563
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	IGI	J:157031
Biological Process	GO:0046851	negative regulation of bone remodeling	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	J:164862
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:154024
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:121773
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:157031
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI	J:135313
Biological Process	GO:2000080	negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:2000270	negative regulation of fibroblast apoptotic process	ISO	J:164563
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:157031
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0043508	negative regulation of JUN kinase activity	IGI	J:147041
Biological Process	GO:0043508	negative regulation of JUN kinase activity	IGI	J:147041
Biological Process	GO:0030279	negative regulation of ossification	ISO	J:164563
Biological Process	GO:0030279	negative regulation of ossification	IMP	J:150387
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IMP	J:89547
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	ISO	J:164563
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	IMP	J:89547
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	ISO	J:155856
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	IMP	J:89547
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:2000041	negative regulation of planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	ISO	J:155856
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IGI	J:147041
Biological Process	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	ISO	J:164563
Biological Process	GO:0014034	neural crest cell fate commitment	IMP	J:157931
Biological Process	GO:0001843	neural tube closure	IGI	J:157031
Biological Process	GO:0021915	neural tube development	IGI	J:157031
Biological Process	GO:0035567	non-canonical Wnt signaling pathway	IBA	J:265628
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:89547
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:0003402	planar cell polarity pathway involved in axis elongation	IGI	J:135313
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IGI	J:135313
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IGI	J:135313
Biological Process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IGI	J:135313
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IMP	J:89547
Biological Process	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISO	J:164563
Biological Process	GO:0045600	positive regulation of fat cell differentiation	ISO	J:78619
Biological Process	GO:2000271	positive regulation of fibroblast apoptotic process	ISO	J:164563
Biological Process	GO:2000052	positive regulation of non-canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	ISO	J:164563
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP	J:136160
Biological Process	GO:0060687	regulation of branching involved in prostate gland morphogenesis	IMP	J:136160
Biological Process	GO:0010564	regulation of cell cycle process	ISO	J:164563
Biological Process	GO:0090175	regulation of establishment of planar polarity	IGI	J:147041
Biological Process	GO:0090175	regulation of establishment of planar polarity	IGI	J:147041
Biological Process	GO:0090175	regulation of establishment of planar polarity	IGI	J:147041
Biological Process	GO:1904956	regulation of midbrain dopaminergic neuron differentiation	IGI	J:190506
Biological Process	GO:0010975	regulation of neuron projection development	IDA	J:190506
Biological Process	GO:0030278	regulation of ossification	ISO	J:155856
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:164563
Biological Process	GO:0009410	response to xenobiotic stimulus	IDA	J:164747
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:152080
Biological Process	GO:0001756	somitogenesis	IEP	J:53153
Biological Process	GO:0001756	somitogenesis	IGI	J:106551
Biological Process	GO:0044345	stromal-epithelial cell signaling involved in prostate gland development	IEP	J:164785
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:130925
Biological Process	GO:0001657	ureteric bud development	IEP	J:112220
Biological Process	GO:0016055	Wnt signaling pathway	IEA	J:60000
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	IGI	J:135313
Biological Process	GO:0090244	Wnt signaling pathway involved in somitogenesis	IGI	J:135313
Biological Process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	IDA	J:136160

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