GO Annotations Graph

• Symbol: Pld2
• Name: phospholipase D2
• ID: MGI:892877

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	IEA	J:72245
Molecular Function	GO:0035091	phosphatidylinositol binding	IEA	J:72247
Molecular Function	GO:0004630	phospholipase D activity	ISO	J:155856
Molecular Function	GO:0004630	phospholipase D activity	TAS	Reactome:R-MMU-1483172
Molecular Function	GO:0004630	phospholipase D activity	IBA	J:265628
Molecular Function	GO:0004630	phospholipase D activity	IDA	J:166815
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:155856
Cellular Component	GO:0031526	brush border membrane	IDA	J:95570
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005789	endoplasmic reticulum membrane	TAS	Reactome:R-MMU-1483172
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0030027	lamellipodium	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:90272
Cellular Component	GO:0098590	plasma membrane region	IBA	J:265628
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Biological Process	GO:0002031	G protein-coupled receptor internalization	IDA	J:90272
Biological Process	GO:0048017	inositol lipid-mediated signaling	IEA	J:72247
Biological Process	GO:0016042	lipid catabolic process	IEA	J:60000
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0006654	phosphatidic acid biosynthetic process	IEA	J:72247
Biological Process	GO:0009395	phospholipid catabolic process	ISO	J:155856
Biological Process	GO:0009395	phospholipid catabolic process	IBA	J:265628
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0043306	positive regulation of mast cell degranulation	ISO	J:155856
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0048260	positive regulation of receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0006898	receptor-mediated endocytosis	IDA	J:90272
Biological Process	GO:0060627	regulation of vesicle-mediated transport	IBA	J:265628
Biological Process	GO:0042542	response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0043434	response to peptide hormone	ISO	J:155856